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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Correlation of Organism Burden and Alveolar Macrophage Counts during Infection with Pneumocystis carinii and Recovery
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Correlation of Organism Burden and Alveolar Macrophage Counts during Infection with Pneumocystis carinii and Recovery

机译：卡氏肺孢子虫感染和恢复过程中生物负荷和肺泡巨噬细胞计数的相关性

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Changes in the number of alveolar macrophages were correlated with organism burden during Pneumocystis carinii infection. The lungs of healthy, dexamethasone-treated, and dexamethasone-treated and P. carinii-infected rats were lavaged with phosphate-buffered saline. Counting of alveolar macrophages in the lavage fluids revealed that P. carinii infection caused a 58% decrease in the number of alveolar macrophages and that higher P. carinii organism burdens caused a more rapid decrease in alveolar macrophage number. As a control, healthy rats were challenged with the same number of organisms as that normally used to generate P. carinii infections in dexamethasone-treated rats. Thirteen days after challenge, these rats had a profound (54%) increase in alveolar macrophage number in response to the challenge, while the number of alveolar macrophages in immunosuppressed and P. carinii-infected rats had decreased significantly by this time point. These experiments created the first animal model to mimic human pneumocystis pneumonia in alveolar macrophage number alterations. Reduction of P. carinii organism numbers by treatment of rats with trimethoprim and sulfamethoxazole brought a slow rebound in alveolar macrophage number, while recovery from P. carinii infection by cessation of immunosuppression brought a rapid rebound in alveolar macrophage number. These results suggest that both the immune state of the host and P. carinii burden affect alveolar macrophage number.
机译：卡氏肺孢子虫感染期间肺泡巨噬细胞数量的变化与生物体负荷相关。健康，地塞米松治疗，地塞米松治疗和 P的肺。用磷酸盐缓冲液灌洗卡里氏菌感染的大鼠。计数灌洗液中的肺泡巨噬细胞，发现 P。卡林氏菌感染导致肺泡巨噬细胞数量减少58％，而 P升高。卡里氏菌的生物负荷导致肺泡巨噬细胞数量的减少更快。作为对照，健康大鼠受到与通常用于产生 P的生物数量相同的生物攻击。地塞米松治疗的大鼠中的卡里氏感染。攻击后十三天，这些大鼠响应攻击后肺泡巨噬细胞数量大幅增加（54％），而免疫抑制和 P的肺泡巨噬细胞数量增加。到此时间点，感染了Carinii 的大鼠已明显减少。这些实验创建了第一个在肺泡巨噬细胞数目改变中模拟人肺囊虫性肺炎的动物模型。减少 P。用甲氧苄啶和磺胺甲恶唑处理大鼠的carinii 生物体数量使肺泡巨噬细胞数量缓慢反弹，同时从 P恢复。停止免疫抑制感染卡里氏菌后，肺泡巨噬细胞数量迅速反弹。这些结果表明宿主和 P的免疫状态均如此。 Carinii 负担会影响肺泡巨噬细胞数量。

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