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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Effect of Bacterial Flora on Postimmunization Gastritis following Oral Vaccination of Mice with Helicobacter pylori Heat Shock Protein 60
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Effect of Bacterial Flora on Postimmunization Gastritis following Oral Vaccination of Mice with Helicobacter pylori Heat Shock Protein 60

机译：幽门螺杆菌热休克蛋白60对小鼠口服疫苗后细菌菌群对免疫后胃炎的影响

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摘要

In order to assess the efficacy of oral Helicobacter pylori heat shock protein 60 (HSP60) as a vaccine, protection against H. pylori infection in specific-pathogen-free (SPF) C57BL/6 and germfree (GF) IQI mice was examined. Prophylactic oral vaccination of these two strains of mice with either H. pylori HSP60 or Escherichia coli GroEL inhibited H. pylori colonization by 90 to 95% at 3 weeks postinfection (p.i.). However, these mice were only partially protected because bacterial loads increased in all animals at 10 weeks p.i. Anti-H. pylori HSP60 immunoglobulin G was detected in serum at 3 weeks p.i. in mice vaccinated with either H. pylori HSP60 or GroEL. Significant increases in the gastritis scores were observed only in SPF mice immunized with H. pylori HSP60. These results indicate that oral vaccination with H. pylori HSP60 has partial protective effects on subsequent H. pylori infection but also induces postimmunization gastritis. However, GF mice immunized with H. pylori HSP60 did not suffer from severe gastritis. Therefore, the presence of bacterial flora appears to contribute to the induction of postimmunization gastritis.
机译：为了评估口服幽门螺杆菌热休克蛋白60（HSP60）作为疫苗的功效，请针对 H进行保护。检查了无特定病原体（SPF）C57BL / 6和无菌（GF）IQI小鼠的幽门螺杆菌感染。用 H对这两种小鼠进行预防性口服疫苗接种。幽门螺杆菌HSP60或大肠杆菌 GroEL抑制 H。感染后3周（p.i.）幽门螺杆菌定植90％至95％。但是，这些小鼠仅部分受到保护，因为所有动物在p.i第10周时细菌负荷都会增加。抗 H。幽门螺杆菌感染3周后血清中检测到幽门螺杆菌HSP60免疫球蛋白G。在接种了 H疫苗的小鼠中。幽门螺杆菌HSP60或GroEL。仅在用 H免疫的SPF小鼠中观察到胃炎评分显着增加。幽门螺杆菌HSP60。这些结果表明 H口服疫苗。幽门螺杆菌HSP60对随后的 H具有部分保护作用。幽门螺杆菌感染，但也会引起免疫后胃炎。然而，用 H免疫的GF小鼠。幽门螺杆菌HSP60没有患上严重的胃炎。因此，细菌菌群的存在似乎有助于诱导免疫后胃炎。

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