Detection by Radioligand Assay of Antibodies against Borna Disease Virus in Patients with Various Psychiatric Disorders

Hidenori Matsunaga; Susumu Tanaka; Fuyoko Sasao; Yoshii Nishino; Masatoshi Takeda; Keizo Tomonaga

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Detection by Radioligand Assay of Antibodies against Borna Disease Virus in Patients with Various Psychiatric Disorders

机译：通过放射配体法检测各种精神疾病患者的博尔纳病病毒抗体

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Using a radioligand assay, which preserves the natural form of the antigen, antibodies against Borna disease virus nucleoprotein and phosphoprotein were detected in 11 and 19 sera of 171 psychiatric patients, respectively. Compared with results by Western blotting, three and nine sera were concordantly positive, respectively. The four sera showing the highest levels of antibodies by radioligand assay were all negative by Western blotting; however, dilution and inhibition tests supported the positive results. Our results suggest the importance of conformational structure to detect human anti-Borna disease virus antibodies.

机译：使用保留抗原天然形式的放射性配体测定法，分别在171名精神病患者的11和19血清中检出了针对Borna病病毒核蛋白和磷蛋白的抗体。与Western blotting结果相比，三个和九个血清分别呈一致阳性。通过放射配体测定显示出最高抗体水平的四个血清通过蛋白质印迹均阴性。但是，稀释和抑制测试支持了阳性结果。我们的结果表明构象结构对检测人类抗博尔纳病病毒抗体的重要性。

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《Clinical and diagnostic laboratory immunology》 |2005年第5期|共6页
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Hidenori Matsunaga; Susumu Tanaka; Fuyoko Sasao; Yoshii Nishino; Masatoshi Takeda; Keizo Tomonaga;
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1. Detection of Borna Disease Virus-Reactive Antibodies from Patients with Psychiatric Disorders and from Horses by Electrochemiluminescence Immunoassay [J] . Kazunari Yamaguchi, Takashi Sawada, Tohru Naraki, Clinical and diagnostic laboratory immunology . 1999,第5期

机译：电化学发光免疫测定法检测精神病患者和马匹的博尔纳病病毒反应性抗体
2. Detection of anti-Borna Disease Virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan. [J] . Terayama H, Nishino Y, Kishi M, Psychiatry research . 2003,第2期

机译：在日本患有精神分裂症和情绪障碍的患者中检测抗博尔纳病病毒（BDV）抗体。
3. Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients. [J] . K Kubo, T Fujiyoshi, M M Yokoyama, Clinical and diagnostic laboratory immunology . 1997,第2期

机译：日本患者中缺乏与Borna病病毒和人类T细胞白血病病毒1型感染与精神疾病相关性。
4. Infection of Borna Disease Virus Impacts Proteome and Histone Lysine Acetylation in Human Oligodendroglia Cells [C] . Xia Liu, Rongzhong Huang, Chengyu Liu, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：诞生疾病病毒的感染会影响人少突（Logodendroglia细胞）蛋白质组和组蛋白赖氨酸乙酰化
5. Development and validation of a blocking enzyme-linked immunosorbent assay for the detection of antibodies against porcine reproductive and respiratory syndrome virus. [D] . Ferrin, Neal Harold. 2004

机译：开发和验证用于检测针对猪繁殖与呼吸综合征病毒的抗体的封闭酶联免疫吸附法。
6. Detection by Radioligand Assay of Antibodies against Borna Disease Virus in Patients with Various Psychiatric Disorders [O] . Hidenori Matsunaga, Susumu Tanaka, Fuyoko Sasao, 2005

机译：通过放射配体法检测各种精神疾病患者的博尔纳病病毒抗体
7. Detection by Radioligand Assay of Antibodies against Borna Disease Virus in Patients with Various Psychiatric Disorders [O] . Matsunaga, Hidenori, Tanaka, Susumu, Sasao, Fuyoko, 2005

机译：通过放射配体法检测各种精神疾病患者的博尔纳病病毒抗体

Detection by Radioligand Assay of Antibodies against Borna Disease Virus in Patients with Various Psychiatric Disorders

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