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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Abnormal CD40 Ligand (CD154) Expression in Human Immunodeficiency Virus-Infected Children
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Abnormal CD40 Ligand (CD154) Expression in Human Immunodeficiency Virus-Infected Children

机译：人类免疫缺陷病毒感染儿童的CD40配体（CD154）表达异常

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The CD40 ligand (CD154), expressed primarily on activated CD4-positive T cells, is a costimulatory molecule involved in B-cell proliferation, germinal center formation, and immunoglobulin class switching. Since B-cell abnormalities including hypergammaglobulinemia and abnormal antibody-specific immune responses are prominent and occur early during the course of pediatric human immunodeficiency virus (HIV) infection, we measured the baseline levels and the induced levels of expression of CD154 on CD3+ CD8? (T helper cells) in HIV-infected children and uninfected children born to HIV-positive mothers. The percentage of CD154+ T helper cells activated in vitro and the level of CD154 expressed per T helper cell (mean fluorescent channel [MFC]) were significantly lower in the HIV-infected children than in the uninfected control group (77% ± 3% versus 89% ± 1%, respectively [P < 0.002], and 261 ± 174 versus 415 ± 130 MFC, respectively [P < 0.03]). The levels of CD154 expressed on resting T helper cells in the HIV-infected group were not significantly different from the levels observed in the control group. In the HIV-infected children, the level of CD154 on activated T helper cells correlated with the level of immunodeficiency, as assessed by the CD4 T-cell levels (correlation coefficient [r] = 0.707,P = 0.003), but did not correlate with the viral load or with any of the serum immunoglobulin concentrations measured in this group of HIV-infected children. The baseline level of CD154 expressed on T helper cells did, however, correlate with the concentration of immunoglobulin A in serum. We conclude that HIV-infected children have impaired regulation of CD154 expression which may contribute to the immune dysregulation commonly observed.
机译：CD40配体（CD154）主要在活化的CD4阳性T细胞上表达，是一种共刺激分子，参与B细胞增殖，生发中心形成和免疫球蛋白类别转换。由于包括高球蛋白血症和异常抗体特异性免疫反应在内的B细胞异常异常突出并且在小儿人类免疫缺陷病毒（HIV）感染过程中发生得较早，因此我们测量了CD3的基线水平和CD154表达的诱导水平。 HIV感染的母亲和HIV阳性母亲所生的未感染孩子中的+ CD8 ？（T辅助细胞）。在HIV感染的儿童中，体外激活的CD154 + T辅助细胞的百分比和每个T辅助细胞表达的CD154（平均荧光通道[MFC]）水平明显低于未感染的对照组。组（分别<77％±3％和89％±1％[ P <0.002]，以及261±174对415±130 MFC [ P <0.03 ]）。 HIV感染组在静息T辅助细胞上表达的CD154的水平与对照组没有明显差异。在感染了艾滋病毒的儿童中，活化的T辅助细胞上CD154的水平与免疫缺陷水平相关，如CD4 T细胞水平所评估（相关系数[ r ] = 0.707， P = 0.003），但与这组感染HIV的儿童的病毒载量或血清免疫球蛋白浓度无关。然而，T辅助细胞上表达的CD154的基线水平确实与血清中免疫球蛋白A的浓度相关。我们得出的结论是，感染HIV的儿童CD154表达的调节受损，这可能导致通常观察到的免疫失调。

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