Insecticide-Treated Bed Nets Reduce Plasma Antibody Levels and Limit the Repertoire of Antibodies to Plasmodium falciparumVariant Surface Antigens

Nikolaj Askjaer; Caroline Maxwell; William Chambo; Trine Staalsoe; Morten Nielsen; Lars Hviid

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Insecticide-Treated Bed Nets Reduce Plasma Antibody Levels and Limit the Repertoire of Antibodies to Plasmodium falciparumVariant Surface Antigens

机译：杀虫剂处理过的蚊帐可降低血浆抗体水平并将抗体库限制于恶性疟原虫变种表面抗原

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The use of insecticide-treated bed nets (ITN) has been documented to reduce malaria morbidity and mortality in areas with endemic malaria, but concerns have been raised that ITN usage could affect the acquisition of malaria immunity. Several lines of evidence have indicated that antibodies against variant surface antigens (VSA) are important in the development of naturally acquired immunity toPlasmodium falciparum malaria and may thus be good indicators of immune status. We have compared the levels of VSA antibodies in plasma from children who have used ITN for 4 years to levels in plasma from children from a nearby village not using ITN. A total of 97 plasma samples were analyzed using 13 different P. falciparum isolates. We found that the children using ITN had significantly lower VSA antibody levels and recognized a smaller proportion of the VSA expressed by the tested parasite isolates than children not using ITN.

机译：使用杀虫剂处理的蚊帐（ITN）可以减少疟疾流行地区的疟疾发病率和死亡率，但是人们担心使用ITN会影响对疟疾免疫力的获取。有几条证据表明，针对变异表面抗原（VSA）的抗体在开发对恶性疟原虫的自然获得性免疫中很重要，因此可能是免疫状态的良好指标。我们将使用ITN 4年的儿童血浆中的VSA抗体水平与附近村庄未使用ITN的儿童血浆中的VSA抗体水平进行了比较。使用13种不同的 P分析了总共97个血浆样品。恶性疟原虫的分离株。我们发现，使用ITN的儿童比不使用ITN的儿童具有显着较低的VSA抗体水平，并且识别出由测试的寄生虫分离株表达的VSA比例较小。 展开▼

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《Clinical and diagnostic laboratory immunology》 |2001年第6期|共3页

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Nikolaj Askjaer; Caroline Maxwell; William Chambo; Trine Staalsoe; Morten Nielsen; Lars Hviid;
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中图分类诊断学;

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1. Human Leukocyte Antigen Class II Alleles Influence Levels of Antibodies to the Plasmodium falciparum Asexual-Stage Apical Membrane Antigen 1 but Not to Merozoite Surface Antigen 2 and Merozoite Surface Protein 1 [J] . Armead H. Johnson, Rose G. F. Leke, Nancy R. Mendell, Infection and immunity . 2004,第5期

机译：人类白细胞抗原II类等位基因对恶性疟原虫无性阶段顶膜抗原1的抗体水平的影响，但对裂殖子表面抗原2和裂殖子表面蛋白1的影响不大。

2. Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3 [J] . Vincent Guiyedi, Christophe Bécavin, Fabien Herbert, Malaria Journal . 2015,第S1期

机译：儿童无症状恶性疟原虫感染与自身抗体产生增加，IL-10血浆水平高以及裂殖子表面蛋白抗体3相关

3. A novel merozoite surface antigen of Plasmodium falciparum (MSP-3) identified by cellular-antibody cooperative mechanism antigenicity and biological activity of antibodies [J] . André Tartar, Claude Oeuvray, Hasnaa Bouharoun-tayoun, Memórias do Instituto Oswaldo Cruz . 1994,第89期

机译：一种新的恶性疟原虫裂殖子表面抗原（MSP-3），通过细胞-抗体合作机制的抗原性和抗体的生物学活性鉴定

4. Sequence-Based Discovery and Meta-Analysis Demonstrates that Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies [C] . Nathan D. Trinklein, Katherine E. Harris, Shelley Force Aldred, Protein Engineering Summit. . 2018

机译：基于序列的发现和荟萃分析表明，固定轻链人类转基因大鼠产生多种抗原特异性抗体的曲目

5. A Molecular Simulation Study of Antibody-Antigen Interactions on Surfaces for the Rational Design of Next-Generation Antibody Microarrays [D] . Bush, Derek B. 2017

机译：抗体-抗原在表面上相互作用的分子模拟研究，用于下一代抗体微阵列的合理设计

6. Note: Insecticide-Treated Bed Nets Reduce Plasma Antibody Levels and Limit the Repertoire of Antibodies to Plasmodium falciparum Variant Surface Antigens [O] . Nikolaj Askjaer, Caroline Maxwell, William Chambo, 2001

机译：注意：杀虫剂处理过的蚊帐可降低血浆抗体水平并限制恶性疟原虫变体表面抗原的抗体种类

7. Insecticide-Treated Bed Nets Reduce Plasma Antibody Levels and Limit the Repertoire of Antibodies to Plasmodium falciparum Variant Surface Antigens [O] . Askjaer, Nikolaj, Maxwell, Caroline, Chambo, William, 2001

机译：杀虫剂处理过的蚊帐可降低血浆抗体水平，并限制恶性疟原虫变体表面抗原的抗体种类

1. ANTIGEN OF PLASMODIUM PHALCIPALM OBTAINED AT TIME OF PENETRATION OF PLASMODIUM PHALCIPALM IN RED CORPUSCLE, ITS PURIFICATION, METHOD FOR DETERMINING ADMINISTRATION DOSE OF SAID ANTIGEN AND ANTIBODY THEREOF AND MALARIA VACCINE CONTAINING SAID ANTIGEN [P] . 外国专利： JPS62135499A . 1987-06-18

机译：红球菌中穿梭虫的血浆中检出的睑板球菌抗原，其纯化，测定SAD抗原剂量的方法及确定其有效剂量的方法以及含有SAID抗原的疟疾疫苗

2. antigenic polypeptide composition, family of purified genes, family of polynucleotides, plasmodium falciparum gene isolated from a family, polynucleotide sequence, protein, antigenic polypeptide, immunogenic compositions, vaccines, use of a recombinant protein, purified recombinant or synthetic fragment antibody antibody, antibody set or antibody fragment, use of a composition, medicament, diagnostic methods, diagnostic kits, recombinant nucleotide sequence, recombinant expression and / or cloning vector, use of a recombinant expression cell and expression vector [P] . 外国专利： BRPI0415784A . 2006-12-26

机译：抗原多肽组成，纯化基因家族，多核苷酸家族，从家族分离的恶性疟原虫基因，多核苷酸序列，蛋白质，抗原多肽，免疫原性组合物，疫苗，重组蛋白的用途，纯化的重组或合成片段抗体抗体，抗体组或抗体片段，组合物的用途，药物，诊断方法，诊断试剂盒，重组核苷酸序列，重组表达和/或克隆载体，重组表达细胞和表达载体的用途

3. antibodies comprising an ion concentration-dependent antigen binding domain, fc region variants, il-8 binding antibodies, methods of producing them and for prolonging or reducing the half-life of an antibody in plasma, pharmaceutical composition, nucleic acid, vector, host cell [P] . 外国专利： BR112017014328A2 . 2018-01-02

机译：包含离子浓度依赖性抗原结合结构域的抗体，fc区变体，il-8结合抗体，产生它们的方法以及用于延长或减少抗体在血浆中的半衰期的方法，药物组合物，核酸，载体，宿主细胞

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Insecticide-Treated Bed Nets Reduce Plasma Antibody Levels and Limit the Repertoire of Antibodies to Plasmodium falciparumVariant Surface Antigens

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