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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Determinants of Staphylococcus aureus Nasal Carriage
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Determinants of Staphylococcus aureus Nasal Carriage

机译：金黄色葡萄球菌鼻支架的决定因素

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Nasal carriage of Staphylococcus aureus has been identified as a risk factor for community-acquired and nosocomial infections. We screened 230 donors of diverse ethnic and socioeconomic backgrounds and identified 62 (27%) whose nasal secretions were colonized by S.aureus. In 18 donors in whom the various regions of the nasal luminal surface were separately sampled, the predominant region of S. aureus colonization was the moist squamous epithelium on the septum adjacent to the nasal ostium. Nasal fluid from carriers was defective in killing endogenousS. aureus and nasal carrier isolates ofS. aureus but not a laboratoryS. aureus strain. Transmission electron microscopy revealed that S.aureus isolates incubated in nasal fluid from carriers for 2 h at 37°C were less damaged than those incubated in noncarrier fluid and were coated with an electron-dense layer. Compared with that from healthy donors and patients with acute rhinitis, nasal fluid from carriers contained elevated concentrations of the neutrophil-derived defensins human neutrophil peptides 1 to 3 (47- and 4-fold increases, respectively), indicative of a neutrophil-mediated inflammatory host response to S.aureus colonization. The concentration of the inducible epithelial antimicrobial peptide human β-defensin 2 was also highly elevated compared to that in healthy donors, in whom the level was below the detection limit, or patients with acute rhinitis (sixfold increase). Thus, nasal carriage of S.aureus takes hold in nasal fluid that is permissive for colonization and induces a local inflammatory response that fails to clear the colonizing bacteria.
机译：经鼻葡萄球菌 金黄色葡萄球菌的携带已被确定为社区获得性和医院感染的危险因素。我们筛选了230名来自不同种族和社会经济背景的捐赠者，并确定了62名（27％）鼻分泌物被 S 。金黄色葡萄球菌定殖。在分别采样鼻腔表面各个区域的18个供体中， S 的主要区域。 金黄色葡萄球菌的定殖是鼻孔附近隔片上的湿润的鳞状上皮。携带者的鼻液不能杀死内源性 S 。 金黄色葡萄球菌和 S 的鼻腔载体分离物。 金黄色，但不是实验室 S 。 aureus 菌株。透射电子显微镜显示，在37°C下于携带者鼻液中孵育2 h的 S 。金黄色葡萄球菌菌株比在非携带者液体中孵育的菌株损害较小，并涂有电子致密层。与健康供体和急性鼻炎患者相比，携带者的鼻液中中性粒细胞衍生的防御素人中性粒细胞肽浓度增加了1至3（分别增加了47和4倍），表明中性粒细胞介导的炎症宿主对 S 。金黄色葡萄球菌定植的反应。与健康供体（其水平低于检测限）或急性鼻炎患者（增加六倍）相比，诱导型上皮抗菌肽人β-防御素2的浓度也高度升高。因此， S 。金黄色葡萄球菌的鼻腔运输可在允许定居的鼻液中保持，并引起无法清除定居细菌的局部炎症反应。

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