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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Protective Antigen and Toxin Neutralization Antibody Patterns in Anthrax Vaccinees Undergoing Serial Plasmapheresis
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Protective Antigen and Toxin Neutralization Antibody Patterns in Anthrax Vaccinees Undergoing Serial Plasmapheresis

机译：进行串联血浆置换的炭疽疫苗中的保护性抗原和毒素中和抗体模式

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Recipients of licensed anthrax vaccine (AVA; Biothrax) could serve as a source of hyperimmune plasma and immunoglobulin for therapy and prophylaxis. We measured serum antibodies during serial weekly to biweekly plasmapheresis in 38 individuals previously vaccinated with 4 to 27 doses of AVA. Immunoglobulin G (IgG) to protective antigen (PA) and toxin neutralization assay (TNA) antibody levels were highly correlated (r = 0.86930 and P < 0.0001 for anti-PA concentration versus TNA concentration). Significant decreases in antibody titer and concentration were observed over time when compared for the number of days from the last AVA injection (P < 0.0001 for both anti-PA and TNA concentration) and for the number of days from the first plasmapheresis (P = 0.0007 for anti-PA concentration and P = 0.0025 for TNA concentration). The rate of the decrease in total IgG concentration (half-life [t1/2] = 198.90 days after first plasmapheresis) was significantly less than the decrease in anti-PA IgG (t1/2 = 63.53 days) (P < 0.0001), indicating that the reduction in anti-PA IgG was more likely due to natural decay than plasmapheresis. The time since the last injection and the time after initial plasmapheresis are important elements in considering an optimal schedule for collecting anthrax hyperimmune plasma. Good correlation between IgG to PA and TNA antibodies suggests that the anti-PA enzyme-linked immunosorbent assay can be used as a high-throughput screen for functional immune reactivity in donor plasma units.
机译：许可的炭疽疫苗（AVA; Biothrax）的接收者可作为治疗和预防用途的超免疫血浆和免疫球蛋白的来源。我们在38位先前接种过4至27剂AVA的个体中，每周一次至每两周一次血浆置换期间测量了血清抗体。免疫球蛋白G（IgG）与保护性抗原（PA）和毒素中和试验（TNA）抗体水平高度相关（ r = 0.86930， P <0.0001对于抗PA浓度对比TNA浓度）。与上次AVA注射后的天数（抗PA和TNA浓度均 P <0.0001）相比，以及自开始注射AVA以来的天数，抗体滴度和浓度随时间的推移均显着下降。第一次血浆清除（抗PA浓度 P = 0.0007，TNA浓度 P = 0.0025）。总IgG浓度的降低率（第一次血浆置换后的半衰期[ t 1/2 ] = 198.90天）明显小于抗PA的降低率IgG（ t 1/2 = 63.53天）（ P <0.0001），表明抗PA IgG降低的可能性更大自然衰减比血浆置换。自上次注射以来的时间和初始血浆清除后的时间是考虑收集炭疽高免疫血浆最佳方案的重要因素。 IgG与PA和TNA抗体之间的良好相关性表明，抗PA酶联免疫吸附测定可以用作供体血浆单位中功能性免疫反应性的高通量筛选。

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