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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Antibody Response to Actinomyces Antigen and Dental Caries Experience: Implications for Caries Susceptibility
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Antibody Response to Actinomyces Antigen and Dental Caries Experience: Implications for Caries Susceptibility

机译：放线菌抗原和龋齿经验的抗体反应：对龋齿易感性的影响

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Fluoridated dentifrices reduce dental caries in subjects who perform effective oral hygiene. Actinomyces naeslundii increases in teeth-adherent microbial biofilms (plaques) in these subjects, and a well-characterized serum immunoglobulin G (IgG) antibody response (Actinomyces antibody [A-Ab]) is also increased. Other studies suggest that a serum IgG antibody response to streptococcal d-alanyl poly(glycerophosphate) (S-Ab) may indicate caries experience associated strongly with gingival health and exposure to fluoridated water. The aim of this study was to investigate relationships between A-Ab response, oral hygiene, S-Ab response, and caries experience. Measurements were made of A-Ab and S-Ab concentrations, caries experience (number of decayed, missing, and filled teeth [DMFT], number of teeth surfaces [DMFS], and number of decayed teeth needing treated [DT]), exposure to fluoridated water (Flu), mean clinical pocket depth (PD; in millimeters), and extent of plaque (PL) and gingival bleeding on probing (BOP). A-Ab concentration, the dependent variable in a multiple regression analysis, increased with S-Ab concentration and decreased with PL and DMFT adjusted for Flu (R2 = 0.51, P < 0.002). Residual associations with age, DMFS, DT, and BOP were not significant. In addition, an elevated A-Ab response, defined from immunoprecipitation and immunoassay measurements, indicated a significant, 30% reduction in DMFT after adjustment for significant age and Flu covariance (analysis of variance with covariance F statistic = 10.6, P < 0.003; S-Ab response and interactions not significant). Thus, an elevated A-Ab response indicates less caries in subjects performing effective oral hygiene using fluoridated dentifrices. Conversely, a low A-Ab response is suggestive of decreased A. naeslundii binding to saliva-coated apatite and greater caries experience, as reported by others.
机译：氟化洁牙剂可减少执行有效口腔卫生的对象的龋齿。在这些受试者中，放线菌Naeslundii 的牙齿附着微生物膜（斑块）增加，并且特征明确的血清免疫球蛋白G（IgG）抗体应答（放线菌抗体[A-Ab ]）也增加了。其他研究表明，血清IgG抗体对链球菌d-丙氨酰聚（磷酸甘油酯）（S-Ab）的反应可能表明龋齿经历与牙龈健康和暴露于氟化水密切相关。这项研究的目的是调查A-Ab反应，口腔卫生，S-Ab反应和龋齿经历之间的关系。测量了A-Ab和S-Ab的浓度，龋齿经历（龋齿的数量，缺失和填充的牙齿[DMFT]，牙齿表面的数量[DMFS]和需要治疗的龋齿的数量[DT]），暴露氟化物（Flu），平均临床囊袋深度（PD;以毫米为单位），斑块程度（PL）和探测时牙龈出血（BOP）。多元回归分析中的因变量A-Ab浓度随S-Ab浓度而增加，而针对Flu（ R 2 = 0.51，< em> P <0.002）。与年龄，DMFS，DT和BOP的残差关联不显着。此外，通过免疫沉淀和免疫分析测量得出的升高的A-Ab响应表明，在针对明显的年龄和流感协方差进行调整后，DMFT显着降低了30％（方差分析，协方差F统计量= 10.6， P < / em> <0.003; S-Ab反应和相互作用不明显）。因此，升高的A-Ab应答表明在使用氟化洁牙剂进行有效口腔卫生的受试者中龋齿较少。相反，低A-Ab反应提示 A降低。如其他人所报道的，naeslundii 与唾液包被的磷灰石结合并具有更好的龋齿体验。

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