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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Neutralizing antibody immune response in children with primary and secondary rotavirus infections.
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Neutralizing antibody immune response in children with primary and secondary rotavirus infections.

机译：中和轮状病毒感染儿童的中和抗体免疫反应。

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We have characterized the neutralizing antibody immune response to six human rotavirus serotypes (G1 to G4, G8, and G9) in Brazilian children with primary and secondary rotavirus infections and correlated the response with the G serotype of the infecting rotavirus strain. Twenty-five children were studied: 17 had a single rotavirus infection, 4 were reinfected once, and 4 experienced three infections. Two of the reinfections were by non-group A rotaviruses. Among the 25 primary infections, we observed homotypic as well as heterotypic responses; the serotype G1 viruses, which accounted for 13 of these infections, induced mostly a homotypic response, while infections by serotype G2 and G4 viruses induced, in addition to the homotypic, a heterotypic response directed primarily to serotype G1. Two of the primary infections induced heterotypic antibodies to 69M, a serotype G8 virus that by RNA electrophoresis analysis was found not to circulate in the population during the time of the study. The specificity of the neutralizing antibody immune response induced by a virus of a given serotype was the same in primary as well as secondary infections. These results indicate that the heterotypic immune response induced in a primary rotavirus infection is an intrinsic property of the virus strain, and although there seem to be general patterns of serotype-specific seroconversion, these may vary from serotype to serotype and from strain to strain within a serotype.
机译：我们已经表征了巴西儿童患有原发性和继发性轮状病毒感染的六种人轮状病毒血清型（G1至G4，G8和G9）的中和抗体免疫应答，并将该应答与感染的轮状病毒株的G血清型相关联。研究了25名儿童：17名患了一次轮状病毒感染，4名再次感染了一次，还有4名经历了3次感染。再感染中有两次是由非A型轮状病毒感染。在25种原发感染中，我们观察到同型和异型反应。在这些感染中占13种的血清型G1病毒主要诱导了同型反应，而除了同型之外，由血清型G2和G4病毒引起的感染还引起了主要针对血清型G1的异型反应。两种主要感染诱导了针对69M的异型抗体，这是一种通过RNA电泳分析得出的血清型G8病毒，在研究期间并未在人群中传播。由给定血清型的病毒诱导的中和抗体免疫应答的特异性在原发性和继发性感染中相同。这些结果表明，在原发性轮状病毒感染中诱导的异型免疫应答是病毒株的固有特性，尽管似乎存在血清型特异性血清转化的一般模式，但这些模式可能因血清型而异，也可能随菌株的不同而不同。血清型。

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