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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Selective decrease in human immunodeficiency virus type 1 (HIV-1)-induced alpha interferon production by peripheral blood mononuclear cells during HIV-1 infection.
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Selective decrease in human immunodeficiency virus type 1 (HIV-1)-induced alpha interferon production by peripheral blood mononuclear cells during HIV-1 infection.

机译：在HIV-1感染过程中，外周血单核细胞选择性降低了人类1型免疫缺陷病毒（HIV-1）诱导的α干扰素的产生。

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We previously reported that human immunodeficiency virus type 1 (HIV-1), herpes simplex virus (HSV), and Sendai virus induce higher levels of alpha interferon (IFN-alpha) in blood dendritic cells than in monocytes of healthy donors. In the present study, the levels of IFN-alpha induced by T-cell tropic (IIIb and RF) and monocytotropic (BaL) strains of HIV-1 and by HSV were significantly decreased in peripheral blood mononuclear cells (PBMCs) derived from subjects with asymptomatic and symptomatic HIV-1 infection. In contrast, Sendai virus, a paramyxovirus that induces proportionally more IFN-alpha in monocytes and B cells than do either HIV-1 or HSV, stimulated normal levels of IFN-alpha in PBMCs from the HIV-1-infected men. The IFN-alpha produced by PBMCs from the HIV-1-seropositive subjects was partially acid labile, whereas the IFN-alpha produced by PBMCs from the HIV-1-seronegative donors was acid stable. We hypothesize that there is a selective defect in IFN-alpha production by peripheral blood dendritic cells, whereas the host retains the IFN-alpha-producing capacity of monocytes and B lymphocytes. The loss of IFN-alpha production in response to HIV-1, herpesviruses, and possibly other pathogens could contribute to the progression of HIV-1 infection and to the development of AIDS.
机译：我们以前曾报道过，人血免疫缺陷病毒1型（HIV-1），单纯疱疹病毒（HSV）和仙台病毒在血液树突状细胞中诱导的α干扰素（IFN-α）水平要高于健康供体的单核细胞。在本研究中，HIV-1的T细胞嗜性（IIIb和RF）和单核细胞（BaL）毒株和HSV诱导的IFN-α水平在患有糖尿病的人的外周血单个核细胞（PBMC）中显着降低。无症状和有症状的HIV-1感染。相反，仙台病毒是一种副粘病毒，在单核细胞和B细胞中比HIV-1或HSV诱导比例更高的IFN-α刺激了HIV-1感染者的PBMC中正常水平的IFN-α。 PBMC从HIV-1血清反应阳性的受试者产生的IFN-α具有部分酸稳定性，而PBMC从HIV-1血清反应阴性的供体产生的IFN-α具有酸稳定性。我们假设外周血树突状细胞的IFN-α生产存在选择性缺陷，而宿主保留了单核细胞和B淋巴细胞的IFN-α生产能力。对HIV-1，疱疹病毒和其他可能的病原体的应答会导致IFN-α的产生减少，这可能会导致HIV-1感染的进展以及艾滋病的发展。

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