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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Anti-human immunodeficiency virus type 1 antibodies of noninfected subjects are not related to autoantibodies occurring in systemic diseases.
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Anti-human immunodeficiency virus type 1 antibodies of noninfected subjects are not related to autoantibodies occurring in systemic diseases.

机译：未感染受试者的抗人免疫缺陷病毒1型抗体与系统性疾病中发生的自身抗体无关。

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Indeterminate Western blot (WB) (immunoblot) patterns for anti-human immunodeficiency virus type 1 (HIV-1) antibodies are often observed when testing serum samples from noninfected individuals. We investigated here the possible involvement of some frequently occurring autoantibodies (anti-SmB/B', U1snRNP [68 kDa, A, and C], Ro/SS-A [60 and 52 kDa], and Jo-1) in the generation of such indeterminate HIV-1 WB. In particular, the role of a reported sequence homology between p24 gag and the SmB/B' autoantigen was investigated. Serum samples were obtained from 50 healthy controls, 51 patients with systemic lupus erythematosus (SLE), 46 with systemic sclerosis, 6 with Sj?gren's disease, 3 with mixed connective tissue disease, and 41 healthy subjects with persistent indeterminate HIV-1 WB. Reactivity to HIV-1 p24 gag was slightly but not significantly more frequent in patients with SLE than in controls (25.5% versus 14.0%; P > 0.1), whereas reactivity to HIV-1 p17 gag was significantly more frequent in the former subjects (23.5% versus 8.0%; P = 0.03). Simultaneous reactivity to p17 and p24 was observed in patients with SLE (11.8%; P = 0.014) or systemic sclerosis (8.7%; P = 0.049) but not in controls. There was no association found between the presence of any autoantibody and the occurrence of indeterminate HIV-1 WB nor between the presence of p24-reactive antibodies and anti-SmB/B'; this indicates that most p24-reactive antibodies are directed to epitopes other than the proline-rich sequences shared by p24 gag and SmB/B'.
机译：测试未感染个体的血清样本时，通常会观察到不确定的1型抗人免疫缺陷病毒（HIV-1）抗体的Western blot（WB）（免疫印迹）模式。我们在这里调查了一代人中某些频繁发生的自身抗体（抗SmB / B'，U1snRNP [68 kDa，A和C]，Ro / SS-A [60和52 kDa]和Jo-1）的可能参与情况这种不确定的HIV-1 WB。特别是，研究了报道的p24 gag与SmB / B'自身抗原之间的序列同源性的作用。从50名健康对照，51例系统性红斑狼疮（SLE），46例系统性硬化症，6例干燥综合征，3例混合性结缔组织病和41例持续不确定的HIV-1 WB健康受试者中获取血清样本。与对照组相比，SLE患者对HIV-1 p24 gag的反应性稍高但不明显（25.5％比14.0％; P> 0.1），而在以前的受试者中，对HIV-1 p17 gag的反应性则更为频繁（ 23.5％对8.0％; P = 0.03）。在SLE（11.8％; P = 0.014）或系统性硬化症（8.7％; P = 0.049）的患者中观察到对p17和p24同时反应，但在对照组中没有。在任何自身抗体的存在与不确定的HIV-1 WB的发生之间，或在p24反应性抗体和抗SmB / B'的存在之间均未发现关联。这表明大多数p24反应性抗体都针对p24 gag和SmB / B'共有的富含脯氨酸的序列以外的表位。

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