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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Serum antibody to lipopolysaccharide antigens of Shigella species among U.S. military personnel deployed to Saudi Arabia and Kuwait during Operations Desert Shield and Desert Storm.
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Serum antibody to lipopolysaccharide antigens of Shigella species among U.S. military personnel deployed to Saudi Arabia and Kuwait during Operations Desert Shield and Desert Storm.

机译：在“沙漠之盾”和“沙漠风暴”行动期间部署到沙特阿拉伯和科威特的美国军事人员中，针对志贺氏菌属物种的脂多糖抗原的血清抗体。

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During Operations Desert Shield and Desert Storm, U.S. troops were at high risk of diarrheal disease due to Shigella spp., particularly Shigella sonnei. In order to better understand the serologic response to Shigella infection, 830 male U.S. combat troops were evaluated before and after the deployment to Saudi Arabia and Kuwait for immunoglobulin A (IgA) and IgG anti-Shigella lipopolysaccharide (LPS) (antibody to S. sonnei form I and Shigella flexneri serotypes 1a, 2a, and 3a) in serum. Just before deployment, 10.3% of the subjects were seropositive for IgA and 18.3% were positive for IgG anti-Shigella LPS. IgA and IgG anti-LPS antibody levels in serum prior to deployment were significantly associated with nonwhite race and ethnicity, birth outside the United States, and antibody to hepatitis A virus and Helicobacter pylori. During the deployment, which lasted for a mean of 131 days, 60% of the subjects reported at least one episode of diarrhea and 15% reported an episode of diarrhea with feverishness; also, 5.5% of the subjects exhibited IgA seroconversion to Shigella LPS and 14.0% exhibited IgG seroconversion. A significant association between the development of diarrheal symptoms and either positive predeployment anti-LPS antibody or seroconversion was not found. These data indicate that in this population of U.S. Desert Storm troops who were at high risk of Shigella infection, there was no apparent relation between IgA or IgG anti-Shigella LPS in serum and diarrheal disease.
机译：在“沙漠之盾”和“沙漠风暴”行动期间，由于志贺氏菌属，特别是索内氏志贺氏菌，美军面临腹泻病的高风险。为了更好地了解对志贺氏菌感染的血清学反应，在部署到沙特阿拉伯和科威特之前和之后，评估了830名美国美军战斗人员的免疫球蛋白A（IgA）和IgG抗志贺氏菌脂多糖（LPS）（S。Sonnei抗体）血清中的I型和弗氏志贺氏菌血清型1a，2a和3a）。即将部署之前，有10.3％的受试者对IgA呈血清阳性，而18.3％的IgG抗志贺氏菌LPS呈阳性。部署前血清中的IgA和IgG抗LPS抗体水平与非白人种族和种族，在美国境外出生以及甲型肝炎病毒和幽门螺杆菌抗体显着相关。在平均持续131天的部署过程中，60％的受试者报告了至少一次腹泻发作，15％的受试者报告了一次发烧腹泻发作。同样，5.5％的受试者表现出IgA血清转化为志贺氏菌LPS，14.0％的受试者表现出IgG血清转化。腹泻症状的发展与阳性预部署抗-LPS抗体或血清转化之间没有显着关联。这些数据表明，在这群高感染志贺氏菌的美国沙漠风暴部队中，血清中的IgA或IgG抗志贺氏菌LPS与腹泻病之间没有明显的关系。

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