Biological Activity of a Mouse-Human Chimeric Immunoglobulin G2 Antibody to Cryptococcus neoformans Polysaccharide

Katherine Westin Kwon; Nikoletta Lendvai; Sherie Morrison; K. Ryan Trinh; Arturo Casadevall

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Biological Activity of a Mouse-Human Chimeric Immunoglobulin G2 Antibody to Cryptococcus neoformans Polysaccharide

机译：小鼠人类嵌合免疫球蛋白G2抗体对新型隐球菌多糖的生物活性。

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The variable regions of the heavy and light chains of the protective murine monoclonal antibody (MAb) 2H1 (m2H1) were expressed with the human constant region genes for immunoglobulin G2 (IgG2) and kappa, respectively, to construct a chimeric antibody (ch2H1). ch2H1 retains the specificity of the parent MAb, exhibits biological activity, and lacks the toxicity of the parent murine IgG1 in chronically infected mice.

机译：用人类免疫球蛋白G2（IgG2）和κ恒定区基因分别表达保护性鼠单克隆抗体（MAb）2H1（m2H1）的重链和轻链可变区，以构建嵌合抗体（ch2H1）。 ch2H1保留了亲本单克隆抗体的特异性，表现出生物学活性，并且在慢性感染的小鼠中缺乏亲本鼠IgG1的毒性。

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《Clinical and diagnostic laboratory immunology》 |2002年第1期|共4页
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Katherine Westin Kwon; Nikoletta Lendvai; Sherie Morrison; K. Ryan Trinh; Arturo Casadevall;
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1. Biological Activity of a Mouse-Human Chimeric Immunoglobulin G2 Antibody to Cryptococcus neoformans Polysaccharide [J] . Katherine Westin Kwon, Nikoletta Lendvai, Sherie Morrison, Clinical and diagnostic laboratory immunology . 2002,第1期

机译：小鼠人类嵌合免疫球蛋白G2抗体对新型隐球菌多糖的生物活性。
2. Construction and Functional Activities of Chimeric Mouse-Human Immunoglobulin G and Immunoglobulin M Antibodies against the Neisseria meningitidis PorA P1.7 and P1.16 Epitopes [J] . Terje E. Michaelsen, ?istein Ihle, Karen Johanne Beckstr?m, Infection and immunity . 2003,第10期

机译：抗脑膜炎奈瑟氏球菌PorA P1.7和P1.16表位的嵌合小鼠-人免疫球蛋白G和免疫球蛋白M抗体的构建和功能活性
3. Occurrences, immunoglobulin classes, and biological activities of antibodies in normal human serum that are reactive with Cryptococcus neoformans glucuronoxylomannan. [J] . D C Houpt, G S Pfrommer, B J Young, Infection and immunity . 1994,第7期

机译：在正常人血清中与新隐球菌葡糖醛酸甘露聚糖有反应性的抗体的出现，免疫球蛋白类别和抗体的生物学活性。
4. Synergistic effect of IL-12 and Il-18 in inducing fungicidal activity of murine peritoneal exudate cells against cryptococcus neoformans through production of IFN- #gamma# by NK cells [C] . T.Zhang, K.Kawakam, H.M.Qureshi, Proceedings of the Fourth China-Jpan international congress of mycology . 1998

机译：IL-12和Il-18协同作用通过NK细胞产生IFN-＃γ＃诱导鼠腹膜渗出液对新型隐球菌的杀真菌活性
5. Production and characterization of monoclonal antibodies specific for Cryptococcus neoformans capsular polysaccharide [D] . Eckert, Thomas Francis 1989

机译：新型隐球菌荚膜多糖特异性单克隆抗体的生产与表征
6. Biological Activity of a Mouse-Human Chimeric Immunoglobulin G2 Antibody to Cryptococcus neoformans Polysaccharide [O] . Katherine Westin Kwon, Nikoletta Lendvai, Sherie Morrison, 2002

机译：小鼠人类嵌合免疫球蛋白G2抗体对新型隐球菌多糖的生物活性。
7. Biological Activity of a Mouse-Human Chimeric Immunoglobulin G2 Antibody to Cryptococcus neoformans Polysaccharide [O] . Westin Kwon, Katherine, Lendvai, Nikoletta, Morrison, Sherie, 2002

机译：小鼠人类嵌合免疫球蛋白G2抗体对新型隐球菌多糖的生物活性。

Biological Activity of a Mouse-Human Chimeric Immunoglobulin G2 Antibody to Cryptococcus neoformans Polysaccharide

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