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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Maintenance of Serum Immunoglobulin G Antibodies to Epstein-Barr Virus (EBV) Nuclear Antigen 2 in Healthy Individuals from Different Age Groups in a Japanese Population with a High Childhood Incidence of Asymptomatic Primary EBV Infection
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Maintenance of Serum Immunoglobulin G Antibodies to Epstein-Barr Virus (EBV) Nuclear Antigen 2 in Healthy Individuals from Different Age Groups in a Japanese Population with a High Childhood Incidence of Asymptomatic Primary EBV Infection

机译：在儿童期无症状原发性EBV感染高发的日本人群中，不同年龄组的健康个体的爱泼斯坦-巴尔病毒（EBV）核抗原2血清免疫球蛋白G抗体的维持

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Immunoglobulin G (IgG) antibodies to Epstein-Barr virus (EBV) nuclear antigens 2 and 1 (EBNA-2 and EBNA-1, respectively) were studied using sera from healthy individuals of a population with a high incidence of asymptomatic primary EBV infections during infancy or childhood in Japan. Two CHO-K1 cell lines expressing EBNA-2 and EBNA-1 were used for anticomplement and indirect immunofluorescence assays. The positivity rate for EBNA-2 IgG rose in the 1- to 2-year age group, increased and remained at a plateau (～45%) between 3 and 29 years of age (3- to 4-, 5- to 9-, 10- to 14-, and 15- to 29-year age groups), and then reached 98% by age 40 (≥40-year age group). Both seropositivity for EBNA-1 and seropositivity for EBNAs in Raji cells (EBNA/Raji) were detected in the 1- to 2-year age group, remained high, and finally reached 100% by age 40. The geometric mean titer (GMT) of EBNA-2 IgG reached a plateau in the 5- to 9- and 10- to 14-year-old groups and remained elevated in the older age groups (15 to 29 and ≥40 years). The GMT of EBNA-1 IgGs increased to a plateau in the 1- to 2-year-old group and remained unchanged in the older age groups. The GMT of EBNA/Raji IgGs also reached a plateau in the 1- to 2-year-old group, remained level throughout the 3- to 14-year age groups, and decreased in the 15- to 29-year-olds. EBNA-2 IgGs emerged earlier than EBNA-1 IgGs in 8 of 10 patients with infectious mononucleosis, who were between 1 and 27 years old, and declined with time in three of eight cases. These results suggest that EBNA-2 IgG antibodies evoked in young children by asymptomatic primary EBV infections remain elevated throughout life, probably because of reactivation of latent and/or exogenous EBV superinfection.
机译：使用来自无症状原发性EBV感染率高的人群健康个体的血清研究了针对爱泼斯坦-巴尔病毒（EBV）核抗原2和1（分别为EBNA-2和EBNA-1）的免疫球蛋白G（IgG）抗体。日本的婴儿期或儿童时期。表达EBNA-2和EBNA-1的两种CHO-K1细胞系用于抗补体和间接免疫荧光测定。 EBNA-2 IgG的阳性率在1至2岁年龄段有所上升，在3至29岁年龄段（3至4岁，5至9岁至9岁之间）保持较高水平（〜45％） ，10至14岁和15至29岁年龄段），然后到40岁（≥40岁年龄组）达到98％。在1至2岁年龄组中检测到Raji细胞中EBNA-1的血清阳性和EBNA的血清阳性（EBNA / Raji），一直很高，并最终在40岁时达到100％。几何平均滴度（GMT）在5至9岁和10至14岁组中，EBNA-2 IgG的水平达到稳定水平，而在较高年龄组（15至29岁和≥40岁）中仍保持升高。 EBNA-1 IgG的GMT在1至2岁组增加至平稳期，而在较高年龄组中则保持不变。 EBNA / Raji IgG的GMT在1至2岁组中也达到了稳定水平，在3至14岁组中一直保持水平，而在15至29岁组中有所下降。在1到27岁之间的10例传染性单核细胞增多症患者中，有8例EBNA-2 IgG的出现早于EBNA-1 IgG，而在8例中有3例的发病率随时间下降。这些结果表明，无症状的原发性EBV感染在幼儿中诱发的EBNA-2 IgG抗体在整个生命中仍然升高，这可能是由于潜伏性和/或外源性EBV超级感染的重新激活。

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