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首页> 外文期刊>CNS neuroscience & therapeutics. >Glia Protein Aquaporin‐4 Regulates Aversive Motivation of Spatial Memory in Morris Water Maze
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Glia Protein Aquaporin‐4 Regulates Aversive Motivation of Spatial Memory in Morris Water Maze

机译：胶质蛋白Aquaporin-4调节莫里斯水迷宫中空间记忆的厌恶动机。

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Summary Aims Although extensive investigation has revealed that an astrocyte‐specific protein aquaporin‐4 ( AQP 4) participates in regulating synaptic plasticity and memory, a functional relationship between AQP 4 and learning processing has not been clearly established. This study was designed to test our hypothesis that AQP 4 modulates the aversive motivation in Morris water maze ( MWM ). Methods and Results Using hidden platform training, we observed that AQP 4 KO mice significantly decreased their swimming velocity compared with wild‐type ( WT ) mice. To test for a relationship between velocities and escape motivation, we removed the platform and subjected a new group of mice similar to the session of hidden platform training. We found that KO mice exhibited a gradual reduction in swimming velocity, while WT mice did not alter their velocity. In the subsequent probe trial, KO mice after no platform training significantly decreased their mean velocity compared with those KO mice after hide platform training. However, all of KO mice were not impaired in their ability to locate a visible, cued escape platform. Conclusions Our findings, along with a previous report that AQP 4 regulates memory consolidation, implicate a novel role for this glial protein in modulating the aversive motivation in spatial learning paradigm.
机译：概述目标尽管大量研究表明，星形胶质细胞特异性蛋白水通道蛋白4（AQP 4）参与调节突触可塑性和记忆，但AQP 4与学习过程之间的功能关系尚不清楚。本研究旨在验证我们的假设，即AQP 4调节莫里斯水迷宫（MWM）中的厌恶动机。方法和结果使用隐藏平台训练，我们观察到与野生型（WT）小鼠相比，AQP 4 KO小鼠的游泳速度显着降低。为了测试速度与逃避动力之间的关系，我们移除了平台，并进行了一组类似于隐藏平台训练的小鼠实验。我们发现KO小鼠表现出逐渐降低的游泳速度，而WT小鼠没有改变其速度。在随后的探针试验中，未进行平台训练的KO小鼠与经过隐藏平台训练的KO小鼠相比，平均速度明显降低。但是，所有KO小鼠定位可见的，提示的逃生平台的能力均未受到损害。结论我们的发现以及先前关于AQP 4调节记忆巩固的报告，暗示了这种神经胶质蛋白在调节空间学习范式中的厌恶动机方面具有新的作用。

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