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首页> 外文期刊>CNS neuroscience & therapeutics. >Change in Plasma Levels of Amino Acid Neurotransmitters and its Correlation with Clinical Heterogeneity in Early Parkinson's Disease Patients
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Change in Plasma Levels of Amino Acid Neurotransmitters and its Correlation with Clinical Heterogeneity in Early Parkinson's Disease Patients

机译：帕金森氏病早期患者血浆氨基酸神经递质的水平变化及其与临床异质性的关系

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Summary Background The correlation between plasma amino acid ( AA ) neurotransmitters and clinical heterogeneity in early patients with Parkinson's disease ( PD ) is still poorly understood. Aims To examine the plasma levels of AA neurotransmitters in early patients with PD and to evaluate their correlation with PD subtypes. Methods Based on the predominant symptoms, fifty‐one patients with PD were enrolled and divided into four subgroups: (1) akinetic‐rigid type ( ART ), (2) tremor‐dominant type ( TDT ), (3) postural instability/gait difficulty type ( PIGD ), and (4) mixed type ( MT ). Plasma levels of AA were measured by HPLC ‐ RF , and their potential diagnostic practicality and their association with PD subtypes were evaluated by the receiver operating characteristic ( ROC ) and correlation analysis, respectively. Results Patients with PD exhibited markedly lower levels of Asp, Glu, Tau, L‐ser, and lower values of Glu/ GABA ratio than healthy controls. The ROC analysis revealed their high sensitivity (77.1–87.5%) and specificity (58.8–88.2%). Furthermore, the glutamic acid (Glu), γ‐aminobutyric acid ( GABA ) level in the PIGD subtype was increased as compared with other subtypes and was negatively correlated with the ART / PIGD ratio. Conclusion The decrease in plasma Asp, Glu, Tau, L‐ser levels, and the value of Glu/ GABA ratio may be helpful for early PD diagnosis. The elevated GABA level may be the biochemical basis for the specific symptoms of PIGD PD .
机译：发明背景帕金森氏病（PD）早期患者的血浆氨基酸（AA）神经递质与临床异质性之间的相关性仍然知之甚少。目的检查早期PD患者的AA神经递质的血浆水平，并评估其与PD亚型的相关性。方法根据主要症状，纳入51名PD患者，并将其分为四个亚组：（1）运动刚性型（ART），（2）震颤型（TDT），（3）姿势不稳/步态难度类型（PIGD）和（4）混合类型（MT）。通过HPLC-RF测量血浆AA水平，并分别通过接受者工作特征（ROC）和相关分析评估其潜在的诊断实用性以及与PD亚型的关联。结果与健康对照组相比，PD患者的Asp，Glu，Tau，L-ser水平显着降低，而Glu / GABA比值降低。 ROC分析显示它们具有很高的敏感性（77.1–87.5％）和特异性（58.8–88.2％）。此外，与其他亚型相比，PIGD亚型中的谷氨酸（Glu），γ-氨基丁酸（GABA）水平升高，并且与ART / PIGD比率呈负相关。结论血浆Asp，Glu，Tau，L-ser水平的降低以及Glu / GABA比的值可能有助于早期PD诊断。 GABA水平升高可能是PIGD PD特定症状的生化基础。

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