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Triptolide with Potential Medicinal Value for Diseases of the Central Nervous System

机译：雷公藤内酯醇具有治疗中枢神经系统疾病的潜在医学价值

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摘要

Summary Tripterygium wilfordii Hook.f. ( TWHF ) has a long history as a T raditional C hinese M edicine ( TCM ) herb that aids in treating inflammatory and autoimmune diseases. The major bioactive component of TWHF is triptolide, which has been recognized to possess a broad spectrum of biological profiles including antiinflammatory, immunosuppressive, antifertility, and antitumor activities, as well as neurotrophic and neuroprotective effects. Limitation of triptolide, such as poor water solubility and severe systemic toxicity, has postponed clinical development and trials; however, the wide range of medicinal value of triptolide has been drawing intensive worldwide attention. In particular, triptolide has been shown to have significant effects on central nervous system ( CNS ) diseases, such as P arkinson's disease, Alzheimer's disease, spinal cord and brain injury, and multiple sclerosis. This review focuses on the potential therapeutic role of triptolide on CNS diseases, and discusses the structural features, potential modifications, and the other pharmacological activities of triptolide.
机译：摘要雷公藤（TWHF）作为传统的中药（TCM）草药具有悠久的历史，可帮助治疗炎症和自身免疫性疾病。 TWHF的主要生物活性成分是雷公藤甲素，它被认为具有广谱的生物学特性，包括抗炎，免疫抑制，抗生育和抗肿瘤活性，以及​​神经营养和神经保护作用。雷公藤甲内酯的局限性，例如水溶性差和严重的全身毒性，已推迟了临床开发和试验;然而，雷公藤甲素的广泛医学价值已引起全世界的广泛关注。特别是，雷公藤甲素已显示对中枢神经系统（CNS）疾病具有重大影响，例如帕金森氏病，阿尔茨海默氏病，脊髓和脑损伤以及多发性硬化症。这篇综述着重于雷公藤甲素在中枢神经系统疾病中的潜在治疗作用，并讨论了雷公藤甲素的结构特征，潜在的修饰和其他药理活性。

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