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首页> 外文期刊>CNS neuroscience & therapeutics. >Effects of Intravenous and Intrathecal Dexmedetomidine in Spinal Anesthesia: A Meta‐Analysis
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Effects of Intravenous and Intrathecal Dexmedetomidine in Spinal Anesthesia: A Meta‐Analysis

机译：静脉麻醉和鞘内注射右美托咪定对脊髓麻醉的影响：一项荟萃分析

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Summary Purpose To assess the effects of dexmedetomidine on the duration of sensory and motor block, postoperative analgesia, hypotension, bradycardia, and side effects in patients undergoing spinal anesthesia. Methods Two researchers searched MEDLINE , EMBASE , and the Cochrane controlled trial register independently for randomized controlled trials comparing dexmedetomidine with a placebo without any language restrictions. Results A total of 412 patients from eight trials were included in this study. The results revealed that dexmedetomidine was statistically significant in prolonging the duration of sensory block (mean difference, MD = 73.55; 95% CI , [55.69, 91.40] P 2 = 89%) and motor block ( MD = 59.11; 95% CI , [29.58, 88.65] P 2 = 91%) and the time to first request for postoperative analgesia ( MD = 245.77, 95% CI , [143.53, 348.00] P 2 = 98%). The occurrence of hypotension ( OR = 0.60, 95% CI , [0.3–1.23], P = 0.40, I 2 = 3%) and side effects ( OR = 0.9, 95% CI , [0.36–2.22], P = 0.88, I 2 = 0%) was not significantly different between dexmedetomidine and placebo. However, dexmedetomidine was associated with more frequent bradycardia requiring atropine ( OR = 7.55; 95% CI , [2.76–20.63], P = 0.63, I 2 = 0%). Conclusions This meta‐analysis has shown that dexmedetomidine prolonged the duration of spinal anesthesia and improved postoperative analgesia and did not increase the incidence of hypotension and adverse events, but needs more atropine to reverse bradycardia.
机译：总结目的评估右美托咪定对接受脊髓麻醉的患者的感觉和运动阻滞持续时间，术后镇痛，低血压，心动过缓以及副作用的影响。方法两名研究人员分别搜索MEDLINE，EMBASE和Cochrane对照试验登记册，以比较右美托咪定与安慰剂且无任何语言限制的随机对照试验。结果本研究共纳入了来自八项试验的412例患者。结果显示，右美托咪定在延长感觉阻滞持续时间（平均差异，MD = 73.55; 95％CI，[55.69，91.40] P 2 = 89％）和运动阻滞（MD = 59.11; 95％CI， [29.58，88.65] P 2 = 91％）和首次要求术后镇痛的时间（MD = 245.77，95％CI，[143.53，348.00] P 2 = 98％）。低血压的发生率（OR = 0.60，95％CI，[0.3-1.23]，P = 0.40，I 2 = 3％）和副作用（OR = 0.9，95％CI，[0.36-2.22]，P = 0.88 ，I 2 = 0％）在右美托咪定和安慰剂之间无显着差异。然而，右美托咪定与需要阿托品的更频繁的心动过缓相关（OR = 7.55; 95％CI，[2.76-20.63]，P = 0.63，I 2 = 0％）。结论这项荟萃分析表明，右美托咪定延长了脊髓麻醉的持续时间，改善了术后镇痛效果，并没有增加低血压和不良事件的发生率，但需要更多的阿托品来逆转心动过缓。

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