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首页> 外文期刊>CNS neuroscience & therapeutics. >Adhesion Molecule CD146 and its Soluble Form Correlate Well with Carotid Atherosclerosis and Plaque Instability
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Adhesion Molecule CD146 and its Soluble Form Correlate Well with Carotid Atherosclerosis and Plaque Instability

机译：粘附分子CD146及其可溶形式与颈动脉粥样硬化和斑块不稳定性很好相关

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Summary Aims Intraplaque neovascularization and foam cell infiltration contribute to the development of unstable plaque, leading to thromboembolism and stroke. Cell adhesion molecules ( CAM s) have been reported to be involved in the progression of atherosclerosis and plaque vulnerability. The aim of this study was to assess the association of adhesion molecule CD 146 with carotid plaque instability. Methods We collected forty atherosclerotic plaques from 40 patients undergoing carotid endarterectomy. The clinical information of each patient was obtained, and the plaque morphology and characteristics were examined by the ultrasound. The CD 146 expressions of the plaques were graded by using semiquantitative scales. The serum level of soluble form of CD 146 was detected by enzyme‐linked immunosorbent assay ( ELISA ). Results CD 146 expression was mainly on the intraplaque blood vessels and infiltrated macrophages. The CD 146 expression was strongly correlated with the matrix metalloproteinase‐9( MMP ‐9)expressions ( P Conclusions Adhesion molecules CD 146 and its soluble form strongly correlated with the development of inflammation of atherosclerosis and plaque instability. CD 146 may be a promising biomarker for monitoring the development and instability of atherosclerotic plaque in patients with carotid diseases.
机译：发明内容目的斑块内新血管形成和泡沫细胞浸润有助于不稳定斑块的发展，导致血栓栓塞和中风。据报道，细胞粘附分子（CAM）与动脉粥样硬化和斑块易损性的发展有关。这项研究的目的是评估粘附分子CD 146与颈动脉斑块不稳定性的关系。方法我们收集了40例接受颈动脉内膜切除术的患者的40个动脉粥样硬化斑块。获得每位患者的临床信息，并通过超声检查斑块形态和特征。使用半定量标度对斑块的CD 146表达进行分级。通过酶联免疫吸附测定（ELISA）检测血清CD 146的可溶性形式。结果CD 146的表达主要在斑块内的血管和浸润的巨噬细胞上。 CD 146的表达与基质金属蛋白酶9（MMP -9）的表达密切相关（P结论粘附分子CD 146及其可溶形式与动脉粥样硬化的炎症发展和斑块的不稳定性密切相关。CD146可能是有前途的生物标志物用于监测颈动脉疾病患者的动脉粥样硬化斑块的发展和不稳定性。

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