...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and diagnostic laboratory immunology >Sodium Bicarbonate Enhances the Severity of Infection in Neutropenic Mice Orally Inoculated with Listeria monocytogenes EGD
【24h】

Sodium Bicarbonate Enhances the Severity of Infection in Neutropenic Mice Orally Inoculated with Listeria monocytogenes EGD

机译：碳酸氢钠增强口服单核细胞增生性李斯特菌EGD接种的中性粒细胞减少小鼠的感染严重程度

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Epidemiological studies have suggested an association between antacid therapy and development of listeriosis in humans. In this study we used a neutropenic mouse model to demonstrate that oral administration of sodium bicarbonate shortly before intragastric (i.g.) inoculation with Listeria monocytogenes EGD (serotype 1/2a) significantly increased the severity of the resulting systemic infection. An explanation for this observation is provided by evidence that L. monocytogenes EGD is rapidly inactivated in synthetic gastric fluid at pH below 5. A second strain of L. monocytogenes (CM [serotype 1/2b]) exhibited little ability to cause systemic infection following i.g. inoculation and was not significantly enhanced by administration of sodium bicarbonate. Strain CM was readily inactivated in synthetic gastric fluid even at pH 7. These data suggest that gastric acidity and enzymes provide some innate defense against gastrointestinal listeriosis in neutropenic mice.
机译：流行病学研究表明，抗酸药与人类李斯特菌病的发展之间存在关联。在这项研究中，我们使用中性粒细胞减少症小鼠模型证明，在胃内（ig）接种单核细胞增生李斯特菌 EGD（血清型1 / 2a）之前不久，口服碳酸氢钠会显着增加系统性感染的严重程度。对此证据的解释是 L。在低于5的pH值的合成胃液中，单核细胞增生 EGD迅速失活。第二株 L。单核细胞增生病（CM [血清型1 / 2b]）几乎没有能力在感染后引起全身感染。接种，并没有给予碳酸氢钠显着增强。即使在pH值为7的情况下，CM菌株也很容易在合成胃液中失活。这些数据表明，胃酸和酶为中性粒细胞减少症小鼠的胃肠道李斯特菌病提供了先天防御。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号