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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Gamma Interferon Inhibits Production of Anti-OspA Borreliacidal Antibody In Vitro
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Gamma Interferon Inhibits Production of Anti-OspA Borreliacidal Antibody In Vitro

机译：γ干扰素抑制体外抗OspA硼酸酸性抗体的产生

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The ability of a Lyme borreliosis vaccine to induce and maintain sustained levels of borreliacidal antibody is necessary for prolonged protection against infection with Borrelia burgdorferi. Vaccination against infection with B. burgdorferi could be improved by determining the mechanism(s) that influences the production of protective borreliacidal antibody. Borreliacidal antibody was inhibited in cultures of lymph node cells obtained from C3H/HeJ mice vaccinated with formalin-inactivated B. burgdorferi and cultured with macrophages and B. burgdorferi and treated with recombinant gamma interferon (rIFN-γ). The suppression of production of outer surface protein A (OspA) borreliacidal antibody by rIFN-γ was not affected by the time of treatment. In addition, treatment with rIFN-γ inhibited the production of other anti-B. burgdorferi antibodies. By contrast, treatment of cultures of immune lymph node cells with anti-IFN-γ marginally increased the production of borreliacidal antibody and enhanced the production of other antibodies directed against B. burgdorferi. These results show that IFN-γ does not play a major role in the production of anti-OspA borreliacidal antibody. Additional studies are needed to determine which cytokine(s) will enhance production of borreliacidal antibody.
机译：莱姆氏疏螺旋体疫苗具有诱导和维持持续水平的疏螺旋体酸性抗体的能力，对于长期保护免受伯氏疏螺旋体感染的保护是必需的。接种针对 B的疫苗。通过确定影响保护性硼酸硼酸抗体产生的机制，可以改善burgdorferi 。在用福尔马林灭活的 B疫苗接种的C3H / HeJ小鼠的淋巴结细胞培养物中，硼瑞酸抗体受到抑制。 burgdorferi ，并用巨噬细胞和 B培养。并用重组γ干扰素（rIFN-γ）治疗。 rIFN-γ抑制外表面蛋白A（OspA）硼酸酸性抗体的产生不受治疗时间的影响。另外，用rIFN-γ治疗抑制了其他抗-em B的产生。 burgdorferi抗体。相反，用抗-IFN-γ处理免疫淋巴结细胞的培养物稍微增加了硼酸酸性抗体的产生并增强了针对 B的其他抗体的产生。 burgdorferi 。这些结果表明，IFN-γ在抗OspA硼瑞酸抗体的产生中没有主要作用。需要进行其他研究以确定哪种细胞因子可以增强硼酸酸性抗体的产生。

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