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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Inflammatory Responses in Blood Samples of Human Immunodeficiency Virus-Infected Patients with Pulmonary Infections
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Inflammatory Responses in Blood Samples of Human Immunodeficiency Virus-Infected Patients with Pulmonary Infections

机译：人类免疫缺陷病毒感染的肺部感染患者血样中的炎症反应

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We analyzed the characteristics of the inflammatory response occurring in blood during pulmonary infections in human immunodeficiency virus (HIV)-infected patients. A prospective study of consecutive hospital admissions of HIV-infected patients with new-onset radiologic pulmonary infiltrates was carried out in a tertiary university hospital from April 1998 to May 2001. Plasma cyclic AMP receptor protein (CRP), interleukin 1β (IL-1β), IL-6, IL-8, IL-10, and tumor necrosis factor alpha (TNF-α) levels were determined at the time of admission and 4, 5, and 6 days later. Patients were included in a protocol addressed to study etiology and outcome of disease. A total of 249 episodes of infection were included, with the main diagnoses being bacterial pneumonia (BP) (118 episodes), Pneumocystis carinii pneumonia (PCP) (41 episodes), and mycobacteriosis (36 episodes). For these three patient groups, at the time of admission the median CRP and cytokine levels were as follows: CRP, 10.2, 3.8 and 5 mg/dl, respectively (P = 0.0001); IL-8, 19, 3, and 2.9 pg/ml (P = 0.045); and TNF-α, 46.4, 44, and 75 pg/ml, respectively (P = 0.029). There were no significant differences in levels of IL-1β, IL-6, or IL-10 among the patient groups. A total of 23 patients died. At the time of admission, HIV-infected patients with BP had higher plasma CRP and IL-8 levels than did PCP and mycobacteriosis patients. TNF-α levels were higher in patients with mycobacteriosis. An elevated IL-8 level (>61 pg/ml) at the time of admission was an independent factor associated with higher mortality (odds ratio, 12; 95% confidence interval, 1.2 to 235.5).
机译：我们分析了人类免疫缺陷病毒（HIV）感染的患者在肺部感染期间血液中发生的炎症反应的特征。从1998年4月至2001年5月，在一家三级大学医院中对连续感染HIV感染的新发放射性肺浸润患者进行了前瞻性研究。血浆环AMP受体蛋白（CRP），白介素1β（IL-1β）在入院时以及第4、5和6天后测定IL-6，IL-8，IL-10和肿瘤坏死因子α（TNF-α）的水平。将患者纳入研究病因和疾病结局的方案中。总共包括249次感染，主要诊断为细菌性肺炎（BP）（118次），卡氏肺孢子虫肺炎（PCP）（41次）和分枝杆菌病（36次）。对于这三个患者组，入院时的中位CRP和细胞因子水平如下：CRP分别为10.2、3.8和5 mg / dl（ P = 0.0001）; IL-8、19、3和2.9 pg / ml（ P = 0.045）;和TNF-α分别为46.4、44和75 pg / ml（ P = 0.029）。患者组之间的IL-1β，IL-6或IL-10水平无显着差异。共有23例患者死亡。入院时，HIV感染的BP患者血浆CRP和IL-8水平高于PCP和分枝杆菌病患者。分枝杆菌病患者的TNF-α水平较高。入院时IL-8水平升高（> 61 pg / ml）是与更高死亡率相关的独立因素（赔率，12; 95％置信区间，1.2至235.5）。

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