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首页> 外文期刊>Comparative Hepatology >Distribution of hepatitis C virus genotypes in patients infected by different sources and its correlation with clinical and virological parameters: a preliminary study
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Distribution of hepatitis C virus genotypes in patients infected by different sources and its correlation with clinical and virological parameters: a preliminary study

机译：丙型肝炎病毒基因型在不同来源感染患者中的分布及其与临床和病毒学参数的相关性：初步研究

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Background Information about genotypes and associated risk factors in hepatitis C virus (HCV) infected patients in Iran is limited. The aim of this study was to identify the HCV genotypes and associated risk factors in a group of HCV infected patients from Iran. Results Genotyping analysis was performed in 156 patients with positive anti-HCV and HCV-RNA. Patients were questioned concerning documented risk factors. Genotypes 1 and 3 were found in 87 (55.8%) and 45 (28.8%) patients, respectively. The most frequent HCV subtype was 1a (37.8), followed by 3a (28.9%) and 1b (16.7%). There was no statistically significant difference between the risk factors analyzed and the acquisition of HCV infection. We further found that 18 (40%) and 17 (37.8%) patients that were intravenous drug users (IVDU) had genotype 1a and 3a respectively. Conclusion Genotypes 3a and 1a in Iran are less prevalent in IVDU than in Europe and USA, but there is a high similarity between the pattern of genotype in IVDU in both Europe and United States, and Iran. However, in this case it can not be due to people migration among countries since history of travel abroad existed only in 6 cases (13.3%).
机译：关于伊朗感染丙型肝炎病毒（HCV）的患者的基因型和相关危险因素的背景信息有限。这项研究的目的是确定一组伊朗感染HCV的患者的HCV基因型和相关的危险因素。结果对156例抗HCV和HCV-RNA阳性的患者进行了基因分型分析。询问患者有关已记录的危险因素。基因型1和3分别发现87（55.8％）和45（28.8％）患者。 HCV最常见的亚型是1a（37.8），其次是3a（28.9％）和1b（16.7％）。分析的危险因素与HCV感染的获得之间没有统计学上的显着差异。我们进一步发现，静脉注射吸毒者（IVDU）的18位（40％）和17位（37.8％）患者分别具有基因型1a和3a。结论伊朗的IVDU中基因型3a和1a的流行程度低于欧洲和美国，但是在欧美的IVDU中的基因型模式与伊朗之间存在高度相似性。然而，在这种情况下，这不可能是由于国家之间的人口迁移，因为出国旅行的历史仅存在6例（13.3％）。

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