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Clinical Application of Prothrombin Complex Concentrate in Blood Management in Patients

机译：凝血酶原复合物浓缩物在患者血液管理中的临床应用

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Management of patients receiving anticoagulants is a major factor in achieving better outcomes. Anticoagulant therapy may need to be discontinued or rapidly reversed before urgent surgery or invasive procedures. In these situations, treatment with concentrated vitamin K, fresh frozen plasma, and/or clotting factors can achieve more rapid anticoagulant reversal than can drug discontinuation alone. Activated prothrombin complex concentrate is used to treat hemophiliac patients with acquired factor VIII inhibitors. Nonactivated prothrombin complex concentrates are used for anticoagulant reversal. The concentrates are effective within minutes of dosing, providing a nearly immediate decrease in the international normalized ratio. The concentrates are lyophilized powders that can be quickly reconstituted, do not require ABO blood typing before use, and contain 25 times the concentration of vitamin Ka??dependent clotting factors compared with fresh frozen plasma. Studies suggest that the concentrates are associated with better clinical end points than is fresh frozen plasma.
机译：接受抗凝剂患者的管理是取得更好疗效的主要因素。在紧急手术或侵入性手术之前，可能需要中断抗凝治疗或迅速撤消抗凝治疗。在这些情况下，与单独停药相比，用浓缩的维生素K，新鲜的冷冻血浆和/或凝血因子进行的治疗可以更快地逆转抗凝剂。活化的凝血酶原复合物浓缩物用于治疗获得性VIII因子抑制剂的血友病患者。未活化的凝血酶原复合物浓缩物用于抗凝剂逆转。浓缩物在给药后数分钟内有效，国际标准化比例几乎立即下降。浓缩物是冻干粉末，可以快速复原，使用前不需要进行ABO血型检查，并且与新鲜冷冻血浆相比，含有25倍的维生素Kα依赖性凝血因子浓度。研究表明，与新鲜冷冻血浆相比，浓缩物具有更好的临床终点。

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