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首页> 外文期刊>Conference Papers in Science >Report of the Pilot Study Done for the Proposed Investigation on the Possible Synergic Effect between High-Dose Ascorbic Acid Application and Oncothermia Treatment
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Report of the Pilot Study Done for the Proposed Investigation on the Possible Synergic Effect between High-Dose Ascorbic Acid Application and Oncothermia Treatment

机译：完成关于大剂量抗坏血酸与肿瘤治疗之间可能协同作用的拟议研究的初步研究报告

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According to recent investigations, the parenteral application of ascorbic acid (vitamin C) at high doses has significant antitumor activity inin vitroassays. The goal of our experiment was to determine the possible potentiating effect of application of high dose pH-neutralized ascorbic acid to the normal oncothermia treatment method. The NMRI mice were inoculated with C26 murine colon carcinoma cell line subcutaneously at both of their femoral regions and were kept till the tumors reached symmetrically 10 mm in diameter. We created four experimental groups, containing 5 male and 5 female animals in each. Both vitamin-C and oncothermia treatments were applied once; ascorbic acid was appliedintra-peritoneally. Oncothermia treatment was applied only to the right limb tumor; the other side will be used as internal control. After the treatment, the animals were sacrificed, and all tumors were removed and analyzed histopathologically. Our main question centers on the comparison of the cell destruction ratio of the various applied treatment regimes, and studies the possible synergy or additive cross-potentiating of the methods. The results of this experiment turned out to be controversial, since the ascorbic acid did not change the remission rate of the allografts and showed no synergy with oncothermia.
机译：根据最近的研究，高剂量的抗坏血酸（维生素C）的肠胃外应用在体外试验中具有显着的抗肿瘤活性。我们实验的目的是确定将大剂量pH中和的抗坏血酸应用于正常的体温治疗方法的可能的增强作用。将NMRI小鼠的两个股骨区域皮下接种C26鼠结肠癌细胞系，并保持至肿瘤直径对称地达到10毫米。我们创建了四个实验组，每个实验组包含5只雄性和5只雌性动物。维生素C和体温治疗均应用一次;腹膜内施用抗坏血酸。肿瘤治疗仅适用于右肢肿瘤;另一侧将用作内部控制。治疗后，处死动物，取出所有肿瘤并进行组织病理学分析。我们的主要问题集中在各种应用治疗方案的细胞破坏率的比较上，并研究了这些方法可能产生的协同作用或加性交叉增强作用。由于抗坏血酸不会改变同种异体移植物的缓解率，并且显示出与低温无关，因此该实验的结果引起了争议。

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