A DOTAMa??based paraCEST agent favoring TSAP geometry for enhanced amide proton chemical shift dispersion and temperature sensitivity

Todd K. Stevens; Mark Milne; Adam A. H. Elmehriki; Mojm#xed; r Such#xfd; Robert Bartha; Robert H. E. Hudson

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A DOTAMa??based paraCEST agent favoring TSAP geometry for enhanced amide proton chemical shift dispersion and temperature sensitivity

机译：基于DOTAMa ??的paraCEST剂，具有TSAP几何形状，可增强酰胺质子的化学位移分散性和温度敏感性

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The Tm3+ chelate of DOTAM [1,4,7,10a??tetrakis(carbamoylmethyl)a??1,4,7,10a??tetraazacyclododecane] possessing sterically demanding ta??butyl amide substitution favors TSAP geometry. This chelate displayed a paraCEST signal associated with the highly shifted amide proton signal at approximately a??100 ppm that was beyond the frequency of macromolecule magnetization transfer. This signal also displayed high temperature dependence (0.57 ppm ?°Ca??1) in the range of 35a??42 ?°C and at neutral pH. Copyright ?? 2013 John Wiley & Sons, Ltd.

机译：具有空间上要求的叔丁基丁基酰胺取代的DOTAM [1，4，7，10a-四（氨基甲酰基甲基）a-1,4,7,10a-四氮杂十二烷]的Tm 3+螯合物有利于TSAP几何形状。该螯合物显示出与高位移的酰胺质子信号相关的paraCEST信号，其大约为αΔ100ppm，这超出了大分子磁化转移的频率。该信号还显示出在35a≤42℃的温度范围和中性pH值下的高温依赖性（0.57 ppm≤Caδ1）。版权?? 2013 John Wiley＆Sons，Ltd.

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《Contrast media & molecular imaging》 |2013年第3期|共4页
作者
Todd K. Stevens; Mark Milne; Adam A. H. Elmehriki; Mojm#xed; r Such#xfd; Robert Bartha; Robert H. E. Hudson;
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中图分类放射医学;
关键词
PARACESTMRItemperatureTSAPSAPthuliumt#x2010butyl amide;

机译：磁共振成像温度TSAPSAP t＆＃x2010丁基酰胺;

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A DOTAMa??based paraCEST agent favoring TSAP geometry for enhanced amide proton chemical shift dispersion and temperature sensitivity

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