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首页> 外文期刊>Contrast media & molecular imaging >The reciprocal linear QUEST analysis method facilitates the measurements of chemical exchange rates with CEST MRI
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The reciprocal linear QUEST analysis method facilitates the measurements of chemical exchange rates with CEST MRI

机译：双向线性QUEST分析方法有助于使用CEST MRI测量化学交换率

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摘要

Magnetic resonance imaging (MRI) contrast media that are detected via chemical exchange saturation transfer (CEST) often require an accurate estimation of their chemical exchange rate, kex. A variety of analysis methods have been proposed to estimate kex, including the nonlinear QUEST analysis method that evaluates the CEST amplitude as a function of saturation time. We have derived a linear version of QUEST, termed the Reciprocal Linear QUEST (RLa??QUEST) method. Our simulations and experimental results show that RLa??QUEST performs as well as QUEST, while providing a more simplistic fitting procedure. Although CEST results should be acquired with saturation power that has a nutation rate that is faster than kex of the CEST agent, an exact determination of the saturation power is not required to accurately estimate kex with RLa??QUEST. This new analysis method requires a determination of the CEST agent's concentration, which is straightforward for the analysis of CEST agents in chemical solutions, but may be a limitation during in vivo CEST MRI studies. Based on the results of this study and previous studies, we provide recommendations for the linear analysis method that should be employed for each type of CEST MRI study. Copyright ?? 2014 John Wiley & Sons, Ltd.
机译：通过化学交换饱和转移（CEST）检测到的磁共振成像（MRI）造影剂通常需要准确估算其化学交换率kex。已经提出了多种分析方法来估计kex，包括非线性QUEST分析方法，该方法评估CEST振幅作为饱和时间的函数。我们得到了QUEST的线性版本，称为倒数线性QUEST（RLa ?? QUEST）方法。我们的仿真和实验结果表明，RLa ?? QUEST的性能与QUEST相同，同时提供了更为简化的拟合过程。尽管应该使用具有比CEST代理的kex快的章动速率的饱和度功率来获取CEST结果，但是并不需要精确确定饱和度才能使用RLa ?? QUEST准确估计kex。这种新的分析方法需要确定CEST剂的浓度，这对于分析化学溶液中的CEST剂很简单，但在体内CEST MRI研究中可能会受到限制。基于本研究和先前研究的结果，我们为每种CEST MRI研究应采用的线性分析方法提供了建议。版权?? 2014 John Wiley＆Sons，Ltd.

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