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首页> 外文期刊>Contemporary Clinical Trials Communications >Impact of financial reimbursement on retention rates in military clinical trial research: A natural experiment within a multi-site randomized effectiveness trial with active duty service members
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Impact of financial reimbursement on retention rates in military clinical trial research: A natural experiment within a multi-site randomized effectiveness trial with active duty service members

机译：报销费用对军事临床试验研究中的保留率的影响：由现役军人进行的多站点随机有效性试验中的自然试验

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IntroductionAchieving adequate retention rates in clinical trials is essential to ensuring meaningful results. Although financial reimbursement is an effective strategy to increase participant retention, current policies restrict the use of federal funds to reimburse U.S. active duty Service members for research participation. It is unknown whether permitting financial reimbursement among this population would improve trial retention rates. A recent randomized effectiveness trial received approval to provide reimbursement to Service member participants several months after recruitment began, creating a natural experiment to study the effects of financial reimbursement on retention.Materials and methodsActive duty Service members recruited from six U.S. military treatment facilities (N?=?666) were enrolled in a collaborative care study and completed assessments at baseline, three-, six-, and 12-months. Data on study assessment completion rates at three- and six-months were analyzed using the mixed-effects binary logit model to determine the probabilities of completing assessments based on reimbursement status.ResultsParticipants who received reimbursement were significantly more likely to complete study assessments at both time-points than participants who did not receive reimbursement (p?
机译：简介在临床试验中达到足够的保留率对于确保有意义的结果至关重要。尽管财务报销是增加参与者保留率的有效策略，但当前的政策限制了使用联邦资金向美国现役军人报销参加研究的费用。尚不知道允许这些人群中的财务报销是否会提高审判的保留率。最近的一项随机有效性试验获得批准，可以在征募开始后的几个月内向服役人员提供报销，从而创建了一项自然实验，以研究财务报销对保留率的影响。材料和方法从美国六个军事治疗机构招募的现役服役人员（否？ =？666）参加了一项合作医疗研究，并在基线，三个月，六个月和十二个月时完成了评估。使用混合效应二元logit模型分析了三个月和六个月的研究评估完成率数据，以根据报销状况确定完成评估的概率。结果获得报销的参与者在两个时间都更有可能完成研究评估得分比未获得报销的参与者高（p？<？0.01）。在三个月和六个月的时间点提供报销的参与者中，调查完成率分别提高了5％和4％。结论结果表明，为服务成员提供研究参与报销与临床试验保留率的适度提高有关。研究结果为研究人员，资助机构和政策制定者在考虑保留策略以最大化军事研究的价值和影响时提供了有用的见识。

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