...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cureus. >Stereotactic Radiosurgery of Colorectal Carcinoma Brain Metastasis: A Multi-Institutional Experience.
【24h】

Stereotactic Radiosurgery of Colorectal Carcinoma Brain Metastasis: A Multi-Institutional Experience.

机译：大肠癌脑转移的立体定向放射外科：多机构经验。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: Colorectal cancer is one of the most common cancers with one of the poorest survival rates following brain metastasis. Only a few studies have described outcomes after radiosurgery and predictors of mortality in these patients. We describe a multi-center experience in the treatment of colorectal cancer metastases to the brain using stereotactic radiosurgery. Material and Methods: A retrospective review of 66 patients treated over 1993 to 2009 with at least one follow-up was undertaken. Median time to death and its predictors were calculated using Kaplan Meier survival analysis and Cox proportional hazard model. Results: Overall median survival for patients with colorectal cancer was 4.05 months with a mortality of 58 (84.06%) patients over a mean follow-up of 7.03+12.44 months. Both survival analysis and multivariate analysis revealed KPS70 as the only significant predictor of survival (median survival KPS 70: 6.91 months versus KPS 70 was 0.31, p=0.001). When total volume did not exceed 5.4 ccsup3/sup, the patients with volume distributed over fewer lesions had improved survival. No such association was observed with higher volumes. Conclusions: SRS moderately improves survival of patients with colorectal cancer metastatic to brain. Higher KPS predicts favorable prognosis in these patients.
机译：目的：大肠癌是最常见的癌症之一，脑转移后生存率最差。只有少数研究描述了放射外科手术后的结局和这些患者的死亡预测因子。我们描述了使用立体定向放射外科手术治疗结直肠癌转移至大脑的多中心经验。材料与方法：回顾性分析1993年至2009年间接受治疗的66例患者，并至少进行了一次随访。使用Kaplan Meier生存分析和Cox比例风险模型计算死亡的中位时间及其预测因子。结果：大肠癌患者的总体中位生存期为4.05个月，平均随访时间为7.03 + 12.44个月，死亡率为58（84.06％）例。生存分析和多变量分析均显示KPS> 70是生存的唯一重要预测指标（KPS> 70的中位生存期：6.91个月，KPS 70为0.31，p = 0.001）。当总体积不超过5.4 cc 3 时，分布在较少病变处的患者的生存期得到了改善。更高的体积没有观察到这种关联。结论：SRS适度提高了结直肠癌转移至脑的患者的生存率。较高的KPS预测这些患者的预后良好。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号