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首页> 外文期刊>Current Journal of Applied Science and Technology >The Role of Radioactive Iodine in ThyrotoxicosisPatients
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The Role of Radioactive Iodine in ThyrotoxicosisPatients

机译：放射性碘在甲状腺毒症患者中的作用

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Aims: The primary objective of this study is to investigate the treatment of Graves' Disease (GD) with radioactive iodine (~(131)I-NaI), presenting the clinical symptoms suffered from patients, and evaluating the level of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) before and after the therapy procedure.Study Design: This project is considered as a retrospective project, non-randomized, observational clinical case series. Clinical symptoms produced by GD were stratified according to patients’ gender and age, and a comparison between T3, T4 and TSH was done before and after the radioiodine therapy.Place and Duration of Study: This study was conducted under supervision of the Department of Nuclear Medicine, King Abdulaziz University Hospital (KAUH) and the Department of Diagnostic Radiology (KAU), Jeddah, KSA, from November 2012 to May 2013.Methodology: The records of patients with clinical diagnosis of Thyrotoxicosis who were registered in the nuclear medicine department during academic year 2012-2013 to perform thyroid scan retrospectively were analyzed. Data from 21 patients was collected before and after the administration of radioiodine therapeutic activity. Thyroid scintigraphy and thyroid functional tests (TFT) were conducted on all patients enrolled in the present study.Results: The most common clinical symptoms produced by GD were tachycardia, weight loss, excessive sweating and tremors. A total of 90% of the patients were under anti-thyroid drug medication before taking radioiodine therapy while 10% were not. TFT results showed that 95% of patients presented abnormal thyroid function. Aside from excessive sweating, no significant association between age and clinical symptoms was observed. A significant increase in TSH level and decrease in T3 and T4 was observed at three-months after therapy procedure. Within six months post-therapy, 60% of patients showed clinical symptoms of hypothyroidism, 30% presented TFT results compatible with normal thyroid function, and only 10% showed no response to treatment.Conclusion: Radioactive iodine is an excellent alternative for GD treatment compared to other therapeutic approaches, presenting less complication than surgery procedure and reverse possibility when patients are treated with anti-thyroid drug medication.
机译：目的：本研究的主要目的是研究放射性碘（〜（131）I-NaI）对格雷夫斯病（GD）的治疗，表现出患者的临床症状，并评估三碘甲状腺素（T3）的水平，甲状腺素（T4）和促甲状腺激素（TSH）的治疗过程。研究设计：该项目被认为是一项回顾性研究，非随机，观察性临床病例系列。 GD产生的临床症状根据患者的性别和年龄进行分层，并且在放射碘治疗前后对T3，T4和TSH进行比较。 2012年11月至2013年5月，在阿卜杜勒阿齐兹国王大学医院（KAUH）和吉达州吉达诊断放射科（KAU）进行医学研究。方法：在临床核查期间在核医学科登记的甲状腺毒症患者回顾性分析2012-2013学年进行甲状腺扫描的情况。在给予放射性碘治疗活性之前和之后，收集了来自21位患者的数据。结果：本病最常见的临床症状为心动过速，体重减轻，出汗过多和震颤。所有患者均进行了甲状腺闪烁显像和甲状腺功能检查（TFT）。接受放射碘治疗之前，共有90％的患者接受了抗甲状腺药物治疗，而没有接受抗甲状腺药物治疗的患者中有10％没有接受。 TFT结果显示95％的患者表现出异常的甲状腺功能。除了出汗过多，没有观察到年龄与临床症状之间的显着关联。在治疗后三个月，观察到TSH水平显着升高，T3和T4降低。在治疗后六个月内，60％的患者表现出甲状腺功能减退的临床症状，30％的患者表现出与正常甲状腺功能兼容的TFT结果，只有10％的患者对治疗无反应。结论：放射性碘是GD治疗的绝佳替代品与其他治疗方法相比，它具有比手术过程更少的并发症，并且在接受抗甲状腺药物治疗的患者中具有相反的可能性。

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