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首页> 外文期刊>Cureus. >What Makes the Optimal Wound Healing Material? A Review of Current Science and Introduction of a Synthetic Nanofabricated Wound Care Scaffold
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What Makes the Optimal Wound Healing Material? A Review of Current Science and Introduction of a Synthetic Nanofabricated Wound Care Scaffold

机译：是什么构成最佳的伤口愈合材料？合成纳米加工伤口护理支架的最新科学进展和介绍

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Wound matrix materials are used to improve the regeneration of dermal and epidermal layers in both acute and chronic wounds. Contemporary wound matrices are primarily composed of biologic materials such as processed xenogeneic and allogeneic tissues. Unfortunately, existing biologic wound matrices possess multiple limitations including poor longevity, durability, strength, and enzymatic resistance required for persistent support for new tissue formation. A fully-synthetic, resorbable electrospun material (Restrata Wound Matrix, Acera, St.Louis, Missouri ) that exhibits structural similarities to the native extracellular matrix offers a new approach to the treatment of acute and chronic wounds. This novel matrix is the first product to combine the advantages of synthetic construction (e.g. resistance to enzymatic degradation, excellent biocompatibility, strength/durability and controlled degradation) with the positive attributes of biologic materials (e.g. biomimetic architecture similar to human extracellular matrix (ECM), fibrous architecture optimized to support cellular migration and proliferation, engineered porosity to encourage tissue ingrowth and vascularization). These features allow RWM to achieve rapid and complete healing of full-thickness wounds that, in preclinical studies, is comparable to Integra Bilayer Wound Matrix (Integra LifeSciences, Plainsboro, New Jersey), a gold standard biologic material with diverse clinical indications in the wound care. Together, this review suggests that the RWM offers a unique fully-synthetic alternative to existing biologic matrices that is effective, widely available, easy to store, simple to apply and low cost.
机译：伤口基质材料用于改善急性和慢性伤口中真皮层和表皮层的再生。当代的伤口基质主要由生物材料组成，例如加工后的异种组织和同种异体组织。不幸的是，现有的生物伤口基质具有多种局限性，包括持久性支持新组织形成所需的低寿命，耐用性，强度和酶抗性。与天然细胞外基质具有结构相似性的全合成，可吸收的电纺材料（Restrata伤口基质，Acera，St.Louis，密苏里州）为急性和慢性伤口的治疗提供了一种新方法。这种新型基质是首个将合成结构的优点（例如，对酶降解的抵抗力，出色的生物相容性，强度/耐久性和受控降解）与生物材料的积极属性（例如，类似于人细胞外基质（ECM）的仿生结构）结合在一起的产品，纤维结构经过优化以支持细胞迁移和增殖，并设计了孔隙度以鼓励组织向内生长和血管化。这些功能使RWM能够快速，完全治愈全层伤口，在临床前研究中，该伤口可与Integra双层伤口基质（Integra LifeSciences，Plainsboro，新泽西州）相媲美，后者是在伤口中具有多种临床适应症的金标准生物材料关心。综上所述，RWM共同提供了一种有效，广泛可用，易于存储，易于使用且成本低廉的现有生物基质的独特的全合成替代物。

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