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首页> 外文期刊>Cosmetics >Evaluation of the Effect of Plant Mixture Ethanol Extracts Containing Biota orientalis L. Extract on Suppression of Sebum in Cultured Sebocytes and on Stimulation of Growth of Keratinocytes Co-cultured with Hair Papilla Cells
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Evaluation of the Effect of Plant Mixture Ethanol Extracts Containing Biota orientalis L. Extract on Suppression of Sebum in Cultured Sebocytes and on Stimulation of Growth of Keratinocytes Co-cultured with Hair Papilla Cells

机译：评价含东方侧柏的植物混合物乙醇提取物对培养的皮脂细胞中皮脂的抑制作用以及对与毛乳头细胞共培养的角质形成细胞生长的刺激作用的评价

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Biota orientalis L. leaf extract (BOLE) is used medically to improve strength and arrest hemorrhage. In China, BOLE has been used in traditional medicine for its antibacterial properties and for hair restoration. In this study, we investigated the mechanism of hair restoration by BOLE from the point of view of the sebum suppressant effect and hair loss prevention. BOLE at 25 or 50 μg/mL final concentrations, a hair growth plant ethanol extract (HGPEE), and a hair growth plant water extract (HGPWE) (the latter two each containing BOLE and other plant compounds), were used to study: (1) the sebum suppressant effect in sebocytes from normal golden hamster ear pinna origin; (2) the effect on the growth of human fetal epidermal keratinocytes; and (3) the effect on gene expression related to hair growth stimulation, with (2) and (3) studied in human fetal epidermal keratinocytes and hair papilla cells. BOLE had a sebum depletion effect in cultured sebocytes; moreover, the amounts of mRNA of the hair growth factors, KGF, VEGF, and G3PDH analyzed by real-time polymerase chain reaction in human hair papilla cells were increased by HGPEE. The amount of mRNA of Wnt10b in cultured epidermal keratinocytes was increased by the addition of BOLE, and the growth of the cultured epidermal keratinocytes was promoted by HGPEE in a two-layer culture system of hair papilla cells and epidermal keratinocytes. HGPEE had a hair growth promotion/hair restoration effect and a sebum suppression effect. Hair restorers containing HGPEE may be useful for stimulating hair growth and suppressing excess scalp sebum in males and females.
机译：侧柏叶提取物（BOLE）在医学上用于提高强度和阻止出血。在中国，BOLE的抗菌特性和头发修复作用已被用于传统医学中。在本研究中，我们从皮脂抑制作用和预防脱发的角度研究了BOLE修复头发的机理。最终浓度为25或50μg/ mL的BOLE，毛发生长植物乙醇提取物（HGPEE）和毛发生长植物水提取物（HGPWE）（后两种分别包含BOLE和其他植物化合物）用于研究： 1）对正常金仓鼠耳廓起源皮脂细胞的皮脂抑制作用; （2）对人胎儿表皮角质形成细胞生长的影响; （3）（2）和（3）在人胎儿表皮角质形成细胞和毛乳头细胞中研究了对与头发生长刺激相关的基因表达的影响。 BOLE在培养的皮脂细胞中具有皮脂耗竭作用;此外，通过实时聚合酶链反应分析了人毛乳头细胞中毛发生长因子，KGF，VEGF和G3PDH的mRNA含量。通过添加BOLE增加了培养的表皮角质形成细胞中Wnt10b的mRNA的量，并且HGPEE在毛发乳头细胞和表皮角质形成细胞的两层培养系统中促进了培养的表皮角质形成细胞的生长。 HGPEE具有促进头发生长/头发恢复作用和抑制皮脂的作用。包含HGPEE的头发修复剂可能有助于刺激男性和女性的头发生长和抑制头皮皮脂过多。

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