...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta Chirurgica Latviensis >The Concept, Diagnostics, Surgical Prevention and Treatment of Hereditary Colorectal Cancer in Nowadays Medicine
【24h】

The Concept, Diagnostics, Surgical Prevention and Treatment of Hereditary Colorectal Cancer in Nowadays Medicine

机译：现代医学中遗传性大肠癌的概念，诊断，外科预防和治疗

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The Concept, Diagnostics, Surgical Prevention and Treatment of Hereditary Colorectal Cancer in Nowadays MedicineColorectal cancer is a frequent cause of oncological morbidity and mortality. It is the second most common cancer in Europe (13.0%) almost matching the frequency of lung cancer, the most widespread malignancy (13.2%). In European Union countries colorectal cancer is the most frequent tumour. Colorectal cancer is also the second most common cause of cancer death in Europe accounting for 11.9% of cancer-related mortality (4). In 20% of colorectal cancer patients, genetic background exists. However, the discovered genetic mutations related to high lifetime risk of colorectal cancer account only for 5-6% of colorectal cancer cases (27). The two main hereditary cancer syndromes involving the large bowel are familial adenomatous polyposis, responsible for 1% of the annual colorectal cancer burden, and hereditary non-polyposis colorectal cancer that accounts for 2-3% of colorectal cancer cases (9). Both syndromes are remarkable not only by the scientific novelty in hereditary cancer research but only for high practical significance as the knowledge about the peculiar risk of primary and metachronous colorectal cancer as well as about certain extracolonic malignancies is necessary to plan the surgical intervention correctly.
机译：当今医学中遗传性大肠癌的概念，诊断，外科预防和治疗大肠癌是肿瘤发病率和死亡率的常见原因。它是欧洲第二常见的癌症（13.0％），几乎与肺癌发生率最高的恶性肿瘤（13.2％）相匹配。在欧盟国家，大肠癌是最常见的肿瘤。在欧洲，结直肠癌也是第二大最常见的癌症死亡原因，占癌症相关死亡率的11.9％（4）。在20％的大肠癌患者中，存在遗传背景。然而，发现的与大肠癌终生高风险相关的基因突变仅占大肠癌病例的5-6％（27）。涉及大肠的两种主要的遗传性癌症综合征是家族性腺瘤性息肉病，占每年大肠癌负担的1％;遗传性非息肉性结直肠癌，占大肠癌病例的2-3％（9）。这两种综合征不仅在遗传性癌症研究中具有新奇的技术，而且具有很高的实际意义，因为对于正确计划手术干预，必须掌握有关原发性和异时性结直肠癌的特殊风险以及某些结肠外恶性肿瘤的知识。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号