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首页> 外文期刊>Acta Cirurgica Brasileira >Effects of hypothermia on lung inflammation in a rat model of meconium aspiration syndrome 1
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Effects of hypothermia on lung inflammation in a rat model of meconium aspiration syndrome 1

机译：亚低温对胎粪吸入综合征大鼠模型肺部炎症的影响1

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Purpose: To evaluate the effects of hypothermia treatment on meconium-induced inflammation. Methods: Fifteen rats were instilled with human meconium (MEC, 1.5 mL/kg, 65 mg/mL) intratracheally and ventilated for 3 hours. Eight rats that were ventilated and not instilled with meconium served as a sham group. In MEC-hypothermia group, the body temperature was lowered to 33±0.5°C. Analysis of the blood gases, interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α in bronchoalveolar lavage (BAL) fluid samples, and histological analyses of the lungs were performed. Results: The BAL fluid TNF-α, IL-1β, IL-6 and IL-8 concentrations were significantly higher in the MEC-hypothermia group than in the MEC-normothermia (p 0.001, p 0.001, p = 0.001, p 0.001, respectively) and sham-controlled groups (p 0.001, p 0.001, p 0.001, p 0.001, respectively). Conclusion: Meconium-induced inflammatory cytokine production is affected by the body temperature control.
机译：目的：评估低温治疗对胎粪诱发的炎症的影响。方法：15只大鼠气管内滴入人胎粪（MEC，1.5 mL / kg，65 mg / mL），并通气3小时。将八只通气且未滴入胎粪的大鼠作为假手术组。 MEC体温过低组的体温降低到33±0.5°C。对支气管肺泡灌洗液（BAL）样本中的血液气体，白介素（IL）-1β，IL-6，IL-8和肿瘤坏死因子（TNF）-α进行分析，并对肺进行组织学分析。结果：MEC低温组的BAL液TNF-α，IL-1β，IL-6和IL-8浓度显着高于MEC正常体温（p <0.001，p <0.001，p = 0.001，p分别<0.001）和假对照组（分别 <0.001，p <0.001，p <0.001，p <0.001）。结论：胎粪诱导的炎症细胞因子的产生受体温控制的影响。

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