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首页> 外文期刊>Acta Cirurgica Brasileira >Effectual components of Polygonum ciliinerve protects against Staphylococcus aureus infection with immunomodulatory functions in C57BL/6 mice 1
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Effectual components of Polygonum ciliinerve protects against Staphylococcus aureus infection with immunomodulatory functions in C57BL/6 mice 1

机译：西葫芦的有效成分具有免疫调节功能，可预防C57BL / 6小鼠的金黄色葡萄球菌感染1

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摘要

Purpose: To investigate the efficacy and mechanisms of root tuber of Polygonum ciliinerve (Nakai) ohwi (rPC) which has been used to treat bacterial infection in traditional Chinese medicine. Methods: With the mouse model of Staphylococcus aureus (S. aureus) pneumonia, the phenotype of rPC treated mice, including body weight, mortality, lung slices and bacterial burden were evaluated. Furthermore, inflammatory factors in bronchoalveolar lavage (BAL) were determined by ELISA and the distribution of T cells in lung was assessed by immunofluorescence assay. Results: rPC treatment could dose-dependently reduce weight loss and mortality in S. aureus- infected mice. Upon 10 mg/ml rPC treatment, S. aureus -infected mice showed about 8 grams increase in body weight (P0.001) and 50% enhancement in mortality. The integrity of lung tissue and bacterial burden were also improved by rPC treatment. Moreover, rPC was found to modulate the immune response in infection. Conclusion: rPC has therapeutic potential for S. aureus infections and pneumonia with immunomodulatory functions.
机译：目的：研究中药治疗细菌感染的何首乌（Nakai）wiwi（rPC）的功效和机理。方法：用金黄色葡萄球菌（S. aureus）肺炎小鼠模型，评估rPC处理的小鼠的表型，包括体重，死亡率，肺切片和细菌负荷。此外，通过ELISA测定支气管肺泡灌洗液（BAL）中的炎性因子，并通过免疫荧光测定法评估肺中T细胞的分布。结果：rPC治疗可以剂量依赖性地减少金黄色葡萄球菌感染小鼠的体重减轻和死亡率。经10 mg / ml rPC处理后，金黄色葡萄球菌感染的小鼠体重增加了约8克（P <0.001），死亡率提高了50％。通过rPC治疗，肺组织的完整性和细菌负担也得到了改善。此外，发现rPC可调节感染中的免疫反应。结论：rPC具有免疫调节功能，对金黄色葡萄球菌感染和肺炎具有治疗潜力。

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