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首页> 外文期刊>Acta histochemica et cytochemica. >Activation of Anterior Cingulate Cortex Extracellular Signal-Regulated Kinase-1 and -2 (ERK1/2) Regulates Acetic Acid-Induced, Pain-Related Anxiety in Adult Female Mice
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Activation of Anterior Cingulate Cortex Extracellular Signal-Regulated Kinase-1 and -2 (ERK1/2) Regulates Acetic Acid-Induced, Pain-Related Anxiety in Adult Female Mice

机译：前扣带回皮层细胞外信号调节激酶-1和-2（ERK1 / 2）的激活调节成年雌性小鼠乙酸诱导的，疼痛相关的焦虑。

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In visceral pain, anxiety and pain occur simultaneously, but the etiogenesis of this effect is not yet well-described. The anterior cingulate cortex (ACC) is known to be associated with the affective response to noxious stimuli. The aim of the current study is to define the role of ACC extracellular signal-regulated (ERK)-1 and-2 (ERK1/2) activity in the development of pain-related anxiety/depression and the nocifensive response in acetic acid (AA)-elicited visceral pain. The model of visceral pain was created by intraperitoneal (ip) injection of AA to female Kunming mice. We found that AA injection resulted in a dynamic, bilateral ERK1/2 activation pattern in the ACC. Inhibition of ERK1/2 activation 2 hr after AA injection by subcutaneous (sc) injection of the mitogen-activating extracellular kinase (MEK) inhibitor, SL327, had no effect on the nocifensive responses, but did attenuate anxiety-like behavior, as determined by elevated plus-maze and open-field testing results. These data suggest that AA-induced visceral pain activates expression of ACC ERK1/2, which regulates visceral pain-related anxiety, but not the nocifensive response.
机译：在内脏痛中，焦虑和疼痛同时发生，但是这种作用的病因尚未得到很好的描述。已知前扣带回皮层（ACC）与对有害刺激的情感反应有关。本研究的目的是确定ACC细胞外信号调节（ERK）-1和2（ERK1 / 2）活性在疼痛相关焦虑/抑郁和乙酸（AA）伤害反应中的作用）引起内脏疼痛。通过向雌性昆明小鼠腹膜内（ip）注射AA建立内脏疼痛模型。我们发现AA注射会在ACC中产生动态的双边ERK1 / 2激活模式。皮下注射（sc）丝裂原活化细胞外激酶（MEK）抑制剂SL327抑制AA注射2小时后，ERK1 / 2激活对伤害反应没有影响，但确实减轻了焦虑样行为，高迷宫和野外测试结果。这些数据表明，AA引起的内脏痛会激活ACC ERK1 / 2的表达，后者调节与内脏痛有关的焦虑，但不会调节伤害反应。

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