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首页> 外文期刊>Acta medica Iranica. >ADHERENCE TO EMPIRIC ANTIBIOTIC THERAPY GUIDELINE IN A REFERRAL TEACHING HOSPITAL, TEHRAN, IRAN
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ADHERENCE TO EMPIRIC ANTIBIOTIC THERAPY GUIDELINE IN A REFERRAL TEACHING HOSPITAL, TEHRAN, IRAN

机译：在伊朗德黑兰推荐的教学医院中遵守经验性抗生素治疗指南

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摘要

Antibiotic guidelines have proven to be a simple and effective intervention to guide the choice of appropriate empiric antibiotic regimens. The goals of this study were to evaluate adherence to guidelines and streamlining of antibiotics. Hospital records of hospitalized patients in infectious diseases ward Imam Khomeini Hospital, Tehran, Iran, from May 2008 to September 2009 were reviewed.Adherence to guideline was defined as the use of empiric antibiotic in accordance with the clinical diagnosis and local guideline recommendations.In this study, 528 patients with a confirmed infectious disease diagnosis were considered for analysis.The four most frequent diagnoses were skin and soft tissue infections, tuberculosis, respiratory tract infections, and HIV associated opportunistic infections. The most frequent prescribed antibiotic was ceftriaxone.Overall adherence to guideline was 70.8% and the adherence for the most frequent diagnosis was 68%. Frequency of compatibility with the guidelines for were administrated regimes on the basis of drug selection, dosage form and drug dosing were 86.2%, 97% and 84.7%, respectively. The mean lag time between patients’ hospital admission and starting empiric therapy was 1.69±4.9 days. In general, physicians’ adherence with guidelines for empiric antibiotic therapy was high in infectious disease ward with a justified delay. Larger studies are required to establish these conclusions.
机译：抗生素指南已被证明是指导选择合适的经验性抗生素方案的简单有效的干预措施。这项研究的目的是评估对指南的遵守情况以及简化抗生素的方法。回顾了2008年5月至2009年9月在伊朗德黑兰的伊玛目霍梅尼医院传染病病房住院患者的病历，并根据临床诊断和当地指南的建议将依从性定义为使用经验性抗生素。这项研究对528例确诊为传染病的患者进行了分析，其中最常见的四个诊断是皮肤和软组织感染，结核，呼吸道感染以及HIV相关的机会性感染。处方中最常用的抗生素是头孢曲松，对指南的总体依从性为70.8％，最常诊断的依从性为68％。根据药物选择，剂型和药物剂量的给药方案，与指南的相容性频率分别为86.2％，97％和84.7％。患者入院与开始经验治疗之间的平均滞后时间为1.69±4.9天。通常，在传染病病房中，医生对经验性抗生素治疗指南的依从性很高，并且有合理的延迟。需要进行较大的研究才能得出这些结论。

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