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首页> 外文期刊>Acta medica (Hradec Kralove) / >Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx
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Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

机译：口腔，咽，喉鳞状细胞癌患者颈淋巴结微转移的检测

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Background: The goal of this prospective study was to determine the frequency of micrometastases in patients with squamous cell carcinoma (SCC) of the oral cavity, pharynx and larynx in whom elective neck dissection was indicated (cN0). Patients and Methods: A total of 12 patients (10 males and 2 females) were enrolled in the study. The age ranged 42–73 years (median 62 years). Elective neck dissection was performed in all patients (8 ipsilateral, 4 bilateral) and a total of 256 lymph nodes were removed and sent for microscopic examination. Results: The presence of tumor cells in cervical lymph nodes was found in 5/12 (42%) patients. Micrometastases of SCC were found in two patients and isolated tumor cells (ITC) in two other patients. In the remaining one patient with oropharyngeal SCC, a micrometastasis of papillary thyroid carcinoma (PTC) was detected. Positive lymph nodes were localized in level II in three patients with SCC of larynx, hypopharynx and tongue base, respectively, in level I in one patient with SCC of oral tongue and in level III in one patient with PTC. Conclusion: Our results indicate that SCC of head and neck has a high potential for creating micrometastases which frequency is higher compared to clinically detected macrometastases. Therefore, elective neck dissection or radiotherapy of the neck should be considered in patients with high risk of occult metastases or micrometastases.
机译：背景：这项前瞻性研究的目的是确定口腔，口腔和咽部鳞状细胞癌（SCC）患者的微转移灶的频率，这些患者需要进行选择性颈淋巴清扫术（cN0）。患者和方法：共有12位患者（10位男性和2位女性）参与了研究。年龄范围为42-73岁（中位数为62岁）。对所有患者（8例同侧，4例双侧）进行了选择性颈部清扫术，共切除了256个淋巴结并送去进行显微镜检查。结果：5/12（42％）患者发现宫颈淋巴结中存在肿瘤细胞。在两名患者中发现了SCC的微转移，在另两名患者中发现了分离的肿瘤细胞（ITC）。在其余一名口咽SCC患者中，检测到乳头状甲状腺癌（PTC）的微转移。阳性淋巴结分别位于三名喉，下咽和舌根SCC患者的II级中，一名口腔SCC患者的I级中以及一名PTC患者的III级中。结论：我们的结果表明，头颈部SCC产生微转移的可能性很高，与临床检测到的宏观转移相比，其发生频率更高。因此，对于隐匿性转移或微转移风险较高的患者，应考虑进行择期颈淋巴清扫术或颈部放疗。

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