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首页> 外文期刊>Acta neurobiologiae experimentalis >Hippocampal asymmetry in angiotensin II modulatory effects on learning and memory in rats
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Hippocampal asymmetry in angiotensin II modulatory effects on learning and memory in rats

机译：海马不对称对大鼠血管紧张素Ⅱ的调节作用

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摘要

Learning and memory effects of angiotensin II (Ang II) microinjected unilaterally (left or right) and bilaterally into hippocampal CA1 area on the background of the inhibited hippocampal angiotensin 1 receptors type (AT1) of male Wistar rats were studied. It was found that the combination (losartan 100 micrograms + Ang II 0.5 micrograms) microinjected bilaterally or into the left CA1 area improved learning and memory in shuttle-box and step through behavioral tests as compared to the respective controls. The effects were more pronounced after injection into the left CA1 area as compared to the right-side. These findings suggest thatAng II infused on the background of the inhibited CA1 hippocampal AT1 receptors ameliorated the cognitive processes. The data show also an asymmetric effect of Ang II on learning and memory processes in the hippocampus. The stronger modulating effect after microinjection of the combination (losartan + Ang II) into the left CA1 hippocampal area suggests a leftward bias in the rat. The results point to a differential distribution of angiotensin II receptors modulating the learning and memory processes in the left and right hippocampal CA1 area.
机译：研究了雄性Wistar大鼠单侧（左或右）和双侧注入海马CA1区域的血管紧张素II（Ang II）的学习和记忆效应。已发现，向两侧或左侧CA1区域显微注射的组合（氯沙坦100微克+ Ang II 0.5微克）与各自的对照组相比，改善了穿梭箱的学习和记忆能力，并通过了行为测试。与右侧相比，注射到左侧CA1区域后效果更加明显。这些发现表明，在抑制的CA1海马AT1受体的背景下注入Ang II可以改善认知过程。数据还显示Ang II对海马学习和记忆过程的不对称作用。将组合物（氯沙坦+ Ang II）微注射到左CA1海马区后，更强的调节作用表明大鼠向左偏。结果表明，血管紧张素II受体的分布在左侧和右侧海马CA1区调节学习和记忆过程。

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