Alzheimer's Disease: Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia (Adv. Sci. 4/2019)

Yifei Lu; Zhongyuan Guo; Yujie Zhang; Chao Li; Yu Zhang; Qin Guo; Qinjun Chen; Xinli Chen; Xi He; Lisha Liu; Chunhui Ruan; Tao Sun; Bin Ji; Weigen Lu; Chen Jiang

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Alzheimer's Disease: Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia (Adv. Sci. 4/2019)

机译：阿尔茨海默氏病：通过早期调节活化的小胶质细胞来改造阿尔茨海默氏病治疗的微环境胶束（Adv。Sci。4/2019）

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An Alzheimer's disease (AD) brain is featured with the oxidative and inflammatory microenvironment caused by overactivated microglia. In article number 1801586 , Chen Jiang and co‐workers design a brain normalizing system to eliminate reactive oxygen species (ROS) and reeducate microglia from an early phase of AD. Through its efficient neuroprotection and microglia modulatory functions, decreased Aβ plaque burdens and improved cognition are achieved.

机译：小胶质细胞过度活化导致的氧化性和炎症性微环境是阿尔茨海默氏病（AD）脑的特征。 Chen Jiang和他的同事在文章1801586中设计了一种大脑正常化系统，以消除活性氧（ROS）并从AD的早期阶段对小胶质细胞进行再教育。通过其有效的神经保护和小胶质细胞调节功能，可以减少Aβ斑块负担并提高认知能力。

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《Advanced Science》 |2019年第4期|共1页
作者
Yifei Lu; Zhongyuan Guo; Yujie Zhang; Chao Li; Yu Zhang; Qin Guo; Qinjun Chen; Xinli Chen; Xi He; Lisha Liu; Chunhui Ruan; Tao Sun; Bin Ji; Weigen Lu; Chen Jiang;
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1. Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia [J] . Yifei Lu, Zhongyuan Guo, Yujie Zhang, Advanced Science . 2018,第4期

机译：通过激活小胶质细胞的早期调节微环境重塑胶束的阿尔茨海默氏病治疗。
2. Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia [J] . Yifei Lu, Zhongyuan Guo, Yujie Zhang, Advanced Science . 2018,第4期

机译：通过激活小胶质细胞的早期调节微环境重塑胶束的阿尔茨海默氏病治疗。
3. Focal Brain Therapy: Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease—A New Navigated Focal Brain Therapy (Adv. Sci. 3/2020) [J] . Roland Beisteiner, Eva Matt, Christina Fan, Advanced Science . 2020,第3期

机译：局灶性脑治疗：颅脉冲刺激在阿尔茨海默病中超声刺激 - 一种新的导航局灶性脑治疗（ADV。SCI。3/2020）
4. Application of TMTcalibrator for Detection of Markers of Microglia Activation in CSF of Alzheimer's Disease Patients [C] . Claire Russell, Vikram Mitra, Amanda Heselgrave, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：Tmtcalibrator在阿尔茨海默病患者CSF中检测微血花症活化标志物的应用
5. Antipsychotic Compounds Inhibit Inflammatory Stimulation of TNFα from Microglia: Relevance to Hemorrhagic Stroke, Alzheimer’s Disease and Other Inflammatory Diseases [D] . Vicari, James Michael 2019

机译：抗精神病化合物抑制小胶质细胞的TNFα的炎症刺激：与出血性中风，阿尔茨海默氏病和其他炎症性疾病的相关性
6. Alzheimers Disease: Microenvironment Remodeling Micelles for Alzheimers Disease Therapy by Early Modulation of Activated Microglia (Adv. Sci. 4/2019) [O] . Yifei Lu, Zhongyuan Guo, Yujie Zhang, 2019

机译：阿尔茨海默氏病：通过早期调节活化的小胶质细胞来改造阿尔茨海默氏病治疗的微环境胶束（Adv。Sci。4/2019）
7. Alzheimer's Disease: Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia (Adv. Sci. 4/2019) [O] . Yifei Lu, Zhongyuan Guo, Yujie Zhang, 2019

机译：Alzheimer的疾病：通过早期调制激活微胶质细胞的Alzheimer疾病治疗微环境改造胶束（ADV。SCI。4/2019）

Alzheimer's Disease: Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia (Adv. Sci. 4/2019)

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