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首页> 外文期刊>Advances in Chemical Engineering and Science >Low Molecular Weight Poly(Lactide-co-Caprolactone) for Tissue Adhesion and Tetracycline Hydrochloride Controlled Release in Wound Management
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Low Molecular Weight Poly(Lactide-co-Caprolactone) for Tissue Adhesion and Tetracycline Hydrochloride Controlled Release in Wound Management

机译：低分子量聚丙交酯-己内酯在伤口处理中用于组织粘附和四环素盐酸盐的控释

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摘要

The use of biopolymers as bioadhesives for human tissue is becoming a preferred alternative to suturing due to their superior adhesive, biocompatible, and biodegradable properties. In this work, low molecular weight poly(L-lactide-co-ε-caprolactone) (P(LA-co-CL) was synthesized to achieve the glass transition temperature (Tg) of the copolymer at ambient temperature so that during application on the skin, the copolymer when combined with chitosan (CHI) into the CHI/P(LA-co-CL) film could provide the strong support at the injury site. Using alcohols with different numbers of hydroxyl groups as the co-initiator in polymerization provided the distinctive characteristics of copolymers. Among all copolymers synthesized, P(LA-co-CL) copolymer using pentaerythritol as the co-initiator when combined with CHI at the ratio of copolymer/CHI at 70/30 yielded the good film properties in tissue adhesion and tetracycline hydrochloride release.
机译：由于其优异的粘合性，生物相容性和可生物降解的特性，将生物聚合物用作人体组织的生物粘合剂已成为缝合的一种替代选择。在这项工作中，合成了低分子量的聚（L-丙交酯-ε-己内酯）（P（LA-co-CL），以在环境温度下达到共聚物的玻璃化转变温度（Tg），以便在涂覆过程中在皮肤上，当共聚物与壳聚糖（CHI）结合成CHI / P（LA-co-CL）膜时，可以在损伤部位提供强大的支持，在聚合反应中使用具有不同羟基数的醇作为共引发剂在所有合成的共聚物中，以季戊四醇为助引发剂的P（LA-co-CL）共聚物与CHI以70/30的共聚物/ CHI比例混合时，在组织中具有良好的薄膜性能粘附力和四环素盐酸盐的释放。

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