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首页> 外文期刊>Acute Medicine & Surgery >Polypharmacy as a risk factor for hospital admission among ambulance‐transported old‐old patients
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Polypharmacy as a risk factor for hospital admission among ambulance‐transported old‐old patients

机译：综合药物治疗是救护车运送的高龄患者住院的危险因素

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Aim The aim of this study was to analyze the relationship between polypharmacy and hospital admission in ambulance‐transported old‐old patients. Methods A retrospective cohort study was conducted of consecutive old‐old patients (aged?≥?85 years) transported by ambulance to a community teaching hospital between A pril and D ecember of 2013. Patients with out‐of‐hospital cardiopulmonary arrest were excluded. Data were collected from the computerized records on the demographics, chief complaints, vital signs, and level of consciousness at arrival, final diagnoses at discharge, and polypharmacy (≥5 medications). The primary outcome was requirement of hospital admission. We also analyzed symptomatic adverse drug events ( ADEs ). Results Of the 3,084 adults (aged?≥?18 years) transported to the hospital during the study period, 381 (13%) were old‐old patients. Of those, 233 (61%) were women, and 261 (69%) were admitted to the hospital. The mean number of their baseline medications was 6.8?±?3.9, and 250/347 patients (72%) were suffering from polypharmacy. Twenty‐seven of the patients (7%) had symptomatic ADEs . Although the ADEs were not related to polypharmacy (P ?=?0.437), logistic regression adjustments for age, sex, and vital signs at arrival showed that patients with polypharmacy were more likely to be admitted to the hospital than were patients without (odds ratio: 2.12 [95% CI , 1.03–4.43]; P ?=?0.042). Conclusions Symptomatic ADEs due to polypharmacy were one of the most preventable causative factors leading to hospital admission of old‐old patients. Polypharmacy could be a major risk for emergency admission to hospital.
机译：目的本研究的目的是分析救护车运送的老年患者的多药和入院之间的关系。方法回顾性队列研究对2013年4月至2013年12月之间由救护车运送到社区教学医院的连续老年患者（≥85岁）进行了研究。排除了院外心肺骤停的患者。从计算机记录中收集数据，这些数据包括人口统计资料，主要投诉，生命体征，到达时的意识水平，出院时的最终诊断以及多药店（≥5种药物）。主要结局是需要入院。我们还分析了症状性药物不良事件（ADEs）。结果在研究期间被运送到医院的3084名成年人（≥18岁）中，有381名（13％）是老年患者。在这些人中，有233名（61％）是女性，有261名（69％）是入院的。他们的基线药物平均数为6.8±±3.9，有250/347例患者（72％）患有多药治疗。二十七名患者（7％）患有有症状的ADE。尽管ADE与多药无关（p = 0.437），但对到达时的年龄，性别和生命体征进行逻辑回归调整显示，与没有多药的患者相比，有多药的患者更有可能入院。 （赔率：2.12 [95％CI，1.03-4.43]; P == 0.042）。结论多药导致的有症状的ADEs是导致老年患者住院的最可预防的病因之一。多元药房可能是紧急入院的主要风险。

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