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Exhaled Nitric Oxide in Patients with Ventilator Associated Pneumonia

机译:呼吸机相关性肺炎患者呼出的一氧化氮

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BACKGROUND: Fraction of exhaled nitric oxide (FENO) is known as a marker of inflammation in asthma, cystic fibrosis and exacerbation of COPD. However, its importance has not been established in patients using mechanical ventilation. We assessed whether FENO is elevated in patients with ventilator associated pneumonia (VAP), and physiologic or pathologic factors affecting levels of FENO in patients with mechanical ventilation. METHODS: All patients (over 18-year-old) using mechanical ventilation were included, and among them, VAP patients were diagnosed on the basis of clinical pulmonary infection score (CPIS). We measured FENO in air collected during the end-expiratory pause via an off-line method. We compared the levels of FENO between patients with VAP and without, and assessed the relationship between FENO and other physiologic or pathologic characteristics; age, gender, PaO2, oxygenation index, CPIS. RESULTS: A total of 43 patients (23 male, mean age 67.7 +/- 10.7) in an ICU were enrolled; 19 of them were VAP-patients (10 male, mean age 64.8 +/- 12.9).
机译:背景:呼出气一氧化氮(FENO)的分数被认为是哮喘,囊性纤维化和COPD恶化的炎症指标。但是,在使用机械通气的患者中其重要性尚未确立。我们评估了呼吸机相关性肺炎(VAP)患者的FENO是否升高,以及影响机械通气患者FENO水平的生理或病理因素。方法:纳入所有机械通气(18岁以上)的患者,其中根据临床肺部感染评分(CPIS)诊断为VAP患者。我们通过离线方法测量了呼气末暂停期间收集的空气中的FENO。我们比较了有和无VAP患者之间的FENO水平,并评估了FENO与其他生理或病理特征之间的关系。年龄,性别,PaO2,氧合指数,CPIS。结果:ICU中共纳入43例患者(23例男性,平均年龄67.7 +/- 10.7)。其中有19位是VAP患者(10位男性,平均年龄64.8 +/- 12.9)。

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