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The Analgesic Effect of Remifentanil on Propofol Injection Pain

机译：瑞芬太尼对异丙酚注射液镇痛的镇痛作用

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BACKGROUND: Pain is a common side-effect of propofol injection. A remifentanil pretreatment has been reported to decrease the incidence and intensity of pain during a propofol injection and has been suggested to act through a central or peripheral effect. This trial was designed to explore the action site of remifentanil on reducing propofol injection pain, using the venous occlusion technique and a time interval between the applications of remifentanil and propofol. METHODS: This randomized, double-blind study was designed to explore the action site of remifentanil on reducing propofol injection pain in 200 patients scheduled for elective surgery. The peripheral properties were examined using the venous occlusion technique for 30 s while a 1 min time interval between remifentanil and propofol injections was allowed for the central effect. Before the propofol injection, group A was pretreated with remifentanil (0.5 microg/ kg) with a venous occlusion, group B with remifentanil and a 1 min interval, and group C with remifentanil with a venous occlusion and a 1 min interval. Pain severity was assessed using a four-point scale.
机译：背景：疼痛是异丙酚注射的常见副作用。据报道，瑞芬太尼预处理可降低丙泊酚注射过程中疼痛的发生率和强度，并已建议通过中枢或外周作用发挥作用。该试验旨在通过静脉阻塞技术和瑞芬太尼与丙泊酚应用之间的时间间隔，探索瑞芬太尼减轻丙泊酚注射痛的作用部位。方法：这项随机，双盲研究旨在探讨瑞芬太尼对计划进行择期手术的200例患者减轻丙泊酚注射痛的作用部位。使用静脉阻塞技术检查了30 s的外周特性，同时在瑞芬太尼和丙泊酚注射之间的1分钟时间间隔中起到了中心作用。丙泊酚注射前，A组先用瑞芬太尼（0.5微克/千克）静脉阻塞，B组先用瑞芬太尼，间隔1分钟，C组先用瑞芬太尼，静脉阻塞，间隔1分钟。使用四点量表评估疼痛严重程度。

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