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Marked Continuous-Time Markov Chain Modelling of Burst Behaviour for Single Ion Channels

机译:单离子通道爆发行为的标记连续时间马尔可夫链建模

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Patch clamp recordings from ion channels often showburstingbehaviour, that is, periods of repetitive activity, which are noticeably separated from each other by periods of inactivity. A number of authors have obtained results for important properties of theoretical and empirical bursts when channel gating is modelled bya continuous-time Markov chain with a finite-state space. We show how the use of marked continuous-time Markov chains can simplify the derivation of (i) the distributions of several burst properties, including the total open time, the total charge transfer, and the number of openings in a burst, and (ii) the form of these distributions when the underlying gating process is time reversible and in equilibrium.
机译:来自离子通道的膜片钳记录通常显示出爆裂行为,即重复活动的时间段,由于不活动的时间段彼此明显分开。当使用具有有限状态空间的连续时间马尔可夫链对信道门控进行建模时,许多作者已经获得了理论和经验突发的重要属性的结果。我们展示了如何使用标记的连续时间马尔可夫链来简化(i)几个突发特性的分布的推导,这些特性包括总打开时间,总电荷转移以及突发中的开孔数量,以及(ii )当基础选通过程是时间可逆的且处于平衡状态时,这些分布的形式。

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