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首页> 外文期刊>Advances in Epidemiology >Paternal Occupational Exposure to Endocrine-Disrupting Chemicals as a Risk Factor for Leukaemia in Children: A Case-Control Study from the North of England
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Paternal Occupational Exposure to Endocrine-Disrupting Chemicals as a Risk Factor for Leukaemia in Children: A Case-Control Study from the North of England

机译：父亲职业暴露于内分泌干扰物是儿童患白血病的危险因素：来自英格兰北部的病例对照研究

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Occupations with exposures to a variety of chemicals, including those thought to be potential endocrine disruptors, have been associated with an increased risk of leukaemia in offspring. We investigated whether an association exists between paternal occupations at birth involving such exposures and risk of leukaemia in offspring. Cases (n=958) were matched, on sex and year of birth, to controls from two independent sources, one other cancers, one cancer-free live births. Paternal occupations at birth were classified, using an occupational exposure matrix, as having “very unlikely,” “possible,” or “likely” exposure to six groups of potential endocrine-disrupting chemicals. There was a significantly increased risk of acute nonlymphocytic leukaemia (ANLL) for polychlorinated organic compounds (OR 1.95, 95% CI 1.08–3.54) only in comparison with cancer-free controls, and for phthalates (OR 1.61, 95% CI 1.00–2.61) only with registry controls. A number of other, including inverse, associations were seen, but limited to one control group only. No associations were seen with likely paternal exposure to heavy metals. The associations identified in this study require further investigation, with better exposure and potential confounding (for example maternal variables) information, to evaluate the likelihood of true associations to assess whether they are real or due to chance.
机译：接触多种化学物质（包括被认为是潜在的内分泌干扰物）的职业与后代患白血病的风险增加有关。我们调查了出生时涉及此类暴露的父亲职业与后代患白血病的风险之间是否存在关联。在性别和出生年份方面，病例（n = 958）与来自两个独立来源，另一种癌症，一种无癌症的活产婴儿的对照相匹配。使用职业暴露矩阵将出生时的父亲职业分类为“极不可能”，“可能”或“可能”暴露于六组潜在破坏内分泌的化学物质。仅与无癌对照相比，多氯有机化合物（OR 1.95，95％CI 1.08-3.54）和邻苯二甲酸盐（OR 1.61，95％CI 1.00-2.61）的急性非淋巴细胞白血病（ANLL）风险显着增加），仅适用于注册表控件。还发现了许多其他关联，包括反向关联，但仅限于一个对照组。没有发现父本可能与重金属接触。本研究中确定的关联需要进一步调查，要有更好的暴露和潜在的混杂因素（例如孕产妇变量）信息，以评估真正关联的可能性，以评估它们是真实的还是由于偶然。

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