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首页> 外文期刊>ACS Omega >Simple Bisthiocarbonohydrazone as a Sensitive, Selective, Colorimetric, and Ratiometric Fluorescent Chemosensor for Picric Acids
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Simple Bisthiocarbonohydrazone as a Sensitive, Selective, Colorimetric, and Ratiometric Fluorescent Chemosensor for Picric Acids

机译：简单的双硫代碳hydr用作苦味酸的灵敏，选择性，比色和比例荧光化学传感器

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摘要

A bisthiocarbonohydrazone-based chemosensor molecule (R1 ) containing a tetrahydro-8-hydroxyquinolizine-9-carboxaldehyde moiety has been synthesized and characterized as a new ratiometric fluorescent probe for picric acid (PA). The ratiometric probe R1 is a highly selective and sensitive colorimetric chemosensor for PA. The association between the chemosensor and PA and the ratiometric performance enabled by the key role of excited state intramolecular proton transfer in the detection process are demonstrated. Selectivity experiments proved that R1 has excellent selectivity to PA over other nitroaromatic chemicals. Importantly, the ratiometric probe exhibited a noteworthy change in both colorimetric and emission color, and this key feature enables R1 to be employed for detection of PA by simple visual inspection in silica-gel-coated thin-layer chromatography plates. Probe R1 has been shown to detect PA up to 3.2 nM at pH 7.4. Microstructural features of R1 and its PA complex have been measured by a field emission scanning electron microscope, and it clearly proves that their morphological features differ dramatically both in shape and size. Density function theory and time-dependent density function theory calculations were performed to establish the sensing mechanism and the electronic properties of probe R1 . Furthermore, we have demonstrated the utility of probe R1 for the detection of PA in live Vero cells for ratiometric fluorescence imaging.
机译：合成了基于双硫代碳oli的化学传感器分子（bR1），该分子含有四氢8-羟基喹啉9-羧醛基，并作为苦味酸（PA）的新型配比荧光探针进行了表征。比例探针R1是用于PA的高度选择性和灵敏的比色化学传感器。证明了化学传感器与PA之间的关联以及通过激发态分子内质子转移在检测过程中的关键作用而实现的比例性能。选择性实验证明，Rb1对PA的选择性优于其他硝基芳香族化合物。重要的是，比例式探针在比色和发射色方面均显示出显着变化，并且该关键特征使得能够通过简单的目视检查在涂有硅胶的薄层色谱板中将R1用于检测PA。探针R1已显示在pH 7.4时可检测到高达3.2 nM的PA。 R 1及其PA配合物的微结构特征已经通过场发射扫描电子显微镜进行了测量，并且清楚地证明了它们的形态特征在形状和尺寸上都存在巨大差异。进行了密度函数理论和随时间变化的密度函数理论计算，以建立探针 R1的传感机理和电子性能。此外，我们已经证明了探针 R1在活体Vero细胞中用于比例荧光成像检测PA的实用性。

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