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首页> 外文期刊>ACS Omega >Engineering of Gadolinium-Decorated Graphene Oxide Nanosheets for Multimodal Bioimaging and Drug Delivery
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Engineering of Gadolinium-Decorated Graphene Oxide Nanosheets for Multimodal Bioimaging and Drug Delivery

机译：d修饰的氧化石墨烯纳米片的多模态生物成像和药物递送工程。

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Engineering of water-dispersible Gd3+ ions-decorated reduced graphene oxide (Gd-rGO) nanosheets (NSs) has been performed. The multifunctional capability of the sample was studied as a novel contrast agent for swept source optical coherence tomography and magnetic resonance imaging, and also as an efficient drug-delivery nanovehicle. The synthesized samples were fabricated in a chemically stable condition, and efforts have been put toward improving its biocompatibility by functionalizing with carbohydrates molecules. Gd incorporation in rGO matrix enhanced the fluorouracil (5-FU) drug loading capacity by 34%. The release of the drug was ～92% within 72 h. Gd-rGO nanosheets showed significant contrast in comparison to optically responsive bare GO for swept source optical coherence tomography. The longitudinal relaxivity rate (r1) of 16.85 mM–1 s–1 for Gd-rGO was recorded, which was 4 times larger than that of the commercially used clinical contrast agent Magnevist (4 mM–1 s–1) at a magnetic field strength of 1.5 T.
机译：已经进行了水分散性Gd3 +离子修饰的还原氧化石墨烯（Gd-rGO）纳米片（NSs）的工程设计。研究了样品的多功能能力，作为扫频源光学相干断层扫描和磁共振成像的新型造影剂，以及有效的药物递送纳米载体。合成的样品是在化学稳定的条件下制备的，并已努力通过利用碳水化合物分子进行功能化来改善其生物相容性。掺入rGO基质中的Gd将氟尿嘧啶（5-FU）的药物负载量提高了34％。 72小时内释药率为〜92％。 Gd-rGO纳米片与用于扫频光源光学相干断层扫描的光响应裸GO相比显示出显着的对比。记录到的Gd-rGO的纵向弛豫率（r1）为16.85 mM–1 s–1，是市售磁场造影剂Magnevist（4 mM–1 s–1）的4倍大。强度为1.5吨

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