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首页> 外文期刊>ACS Omega >Development of a 68Ge/68Ga Generator System Using Polysaccharide Polymers and Its Application in PET Imaging of Tropical Infectious Diseases
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Development of a 68Ge/68Ga Generator System Using Polysaccharide Polymers and Its Application in PET Imaging of Tropical Infectious Diseases

机译：用多糖聚合物开发 68 Ge / 68 Ga发生器系统及其在热带传染病PET成像中的应用

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Gallium-68 (~(68)Ga) is a positron emitter for clinical positron emission tomography (PET) applications that can be produced by a ~(68)Ge/~(68)Ga generator without cyclotron. However, commercially available ~(68)Ge/~(68)Ga generator systems require multiple steps for the preparation of ~(68)Ga radiopharmaceuticals and are sometimes plagued by metallic impurities in the ~(68)Ga eluent. We developed a ~(68)Ge/~(68)Ga generator system using polysaccharide-based adsorbents and direct application of the generator-eluted ~(68)Ga-citrate to PET imaging of tropical infectious diseases. N -Methylglucamine (MG) as a ~(68)Ge-adsorbing unit (Sepha-MGs) was introduced to a series of Sephadex G-10, G-15, G-25, G-50, and G-75. In the batch method, over 97% of the ~(68)Ge in the solution was adsorbed onto the Sepha-MG series within 15 min. In particular, ~(68)Ge was effectively adsorbed on the Sepha(15)-MG packed columns and 70–80% of the ~(68)Ga was eluted by 1 mL of 0.1 M trisodium citrate with low ~(68)Ge contamination (<0.001%). The chemical form of the generator-eluted ~(68)Ga solution was identified as ~(68)Ga-citrate. In PET studies, affected regions in mice infected with Leishmania and severe fever with thrombocytopenia syndrome virus were clearly visualized using the ~(68)Ga-citrate. Sepha-MGs are useful adsorbents for ~(68)Ge/~(68)Ga generator systems with high ~(68)Ga elution efficiency and minimal ~(68)Ge breakthrough. These results indicated that eluted ~(68)Ga-citrate can be directly used for PET imaging of infectious sites in mice. This novel generator system may be useful for straightforward PET imaging of infection in clinical practice.
机译：镓68（〜（68）Ga）是一种用于临床正电子发射断层扫描（PET）应用的正电子发射器，可由不带回旋加速器的〜（68）Ge /〜（68）Ga发生器产生。但是，可商购的〜（68）Ge /〜（68）Ga生成器系统需要多个步骤来制备〜（68）Ga放射性药物，有时会被〜（68）Ga洗脱液中的金属杂质所困扰。我们开发了使用基于多糖的吸附剂的〜（68）Ge /〜（68）Ga生成器系统，并将生成器洗脱的〜（68）Ga-柠檬酸盐直接应用于热带感染性疾病的PET成像。将N-甲基葡糖胺（MG）作为〜（68）Ge吸附单元（Sepha-MGs）引入到一系列Sephadex G-10，G-15，G-25，G-50和G- 75。在分批方法中，溶液中超过97％的〜（68）Ge在15分钟内被吸附到Sepha-MG系列上。特别是，〜（68）Ge有效地吸附在Sepha（15）-MG填充柱上，而〜（68）Ga的70–80％被1 mL含低〜（68）Ge的0.1 M柠檬酸三钠洗脱污染（<0.001％）。发生器洗脱的〜（68）Ga溶液的化学形式被确定为〜（68）Ga-柠檬酸盐。在PET研究中，使用〜（68）Ga-柠檬酸盐可以清晰地观察到感染利什曼原虫和血小板减少症候群病毒的严重发烧的小鼠的受影响区域。 Sepha-MGs是〜（68）Ge /〜（68）Ga生成器系统的有用吸附剂，具有高〜（68）Ga洗脱效率和极低的〜（68）Ge穿透率。这些结果表明，洗脱的柠檬酸〜（68）Ga可直接用于小鼠感染部位的PET成像。在临床实践中，这种新颖的发生器系统可用于直接的PET感染成像。

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