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首页> 外文期刊>Advances in Sexual Medicine >Effects of Sertraline on Sperm Motility, Number and Viability and Its Relation to Blood Levels of Testosterone, FSH and LH in Adult Male Mice
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Effects of Sertraline on Sperm Motility, Number and Viability and Its Relation to Blood Levels of Testosterone, FSH and LH in Adult Male Mice

机译：舍曲林对成年雄性小鼠精子运动，数量和生存力的影响及其与睾丸激素，FSH和LH的关系

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The aim of this study was to investigate the effects of Sertraline on gonad-pituitary cycle (Testosterone, FSH and LH) and reproductive cells in adult male Balb/C mice. Adult male Balb/C mice were divided into the following 5 groups: control group with no treatment, sham group which received solvent, and the experimental groups which received one dose of Sertraline (0.0178 mg/kg) in the first group, two doses of Sertraline (0.0356 mg/kg) in the second group, and three doses of Sertraline (0.0534 mg/kg) in the third group. Mice were anaesthetized after 7 weeks. Serum samples were collected and Testosterone, FSH and LH levels of serum were assayed. Vase deferans were analyzed for motility, number and viability of sperms. The results of this study showed that the viability, count and motility of sperms were decreased. Testosterone level of blood was also decreased while FSH was increased. There was no significant change in LH level. It is suggested that Sertraline at higher dose decreases sperm production and has the potential to affect adversely fertility in male mice.
机译：这项研究的目的是研究舍曲林对成年雄性Balb / C小鼠性腺-垂体循环（睾丸激素，FSH和LH）和生殖细胞的影响。成年雄性Balb / C小鼠分为以下5组：未治疗的对照组，接受溶剂的假手术组，以及在第一组中接受一剂舍曲林（0.0178 mg / kg）的实验组，两剂第二组为舍曲林（0.0356 mg / kg），第三组为三剂舍曲林（0.0534 mg / kg）。 7周后麻醉小鼠。收集血清样品并测定血清的睾丸激素，FSH和LH水平。分析了花瓶精子的活力，数量和活力。研究结果表明，精子的活力，数量和活力下降。睾丸激素水平也下降，而FSH升高。 LH水平无明显变化。提示较高剂量的舍曲林会降低精子产生，并有可能影响雄性小鼠的不利生育能力。

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